ArticleJournal of pharmacy & bioallied sciences2014
The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats.
Article in Journal of pharmacy & bioallied sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 39 citations in OpenAlex.
- Computational screening of natural compounds from traditional Persian medicinal plant for the finding of potential antidepressant.Scientific reports · 2026Article
- An Updated Comprehensive Review of Plants and Herbal Compounds with Antiasthmatic Effect.Evidence-based complementary and alternative medicine : eCAM · 2024Review
- Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder.Pharmaceutical biology · 2022Article
- The potential ofFrontiers in pharmacology · 2022Review
- Investigation of the relationship between chronic montelukast treatment, asthma and depression-like behavior in mice.Experimental and therapeutic medicine · 2021Article
- Awareness and current knowledge of epilepsy.Metabolic brain disease · 2020Review
- Evaluation and comparison of the antidepressant-like activity ofResearch in pharmaceutical sciences · 2019Article
- The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats.Veterinary research forum : an international quarterly journal · 2019Article
- The roles of valerenic acid on BDNF expression in the SH-SY5Y cell.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Deletion of ovarian hormones induces a sickness behavior in rats comparable to the effect of lipopolysaccharide.Neurology research international · 2015Article
- Diene Valepotriates from Valeriana glechomifolia Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats.Avicenna journal of phytomedicineArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroimmune factors have been considered as contributors to the pathogenesis of depression. Beside other therapeutic effects, Valeriana officinalis L., have been suggested to have anti-inflammatory effects. In the present study, the effects of V. officinalis L. hydro alcoholic extract was investigated on depression like behavior in ovalbumin sensitized rats. MATERIALS AND
methodsA total of 50 Wistar rats were divided into five groups: Group 1 (control group) received saline instead of Valeriana officinalis L. extract. The animals in group 2 (sensitized) were treated by saline instead of the extract and were sensitized using the ovalbumin. Groups 3-5 (Sent - Ext 50), (Sent - Ext 100) and (Sent - Ext 200) were treated by 50, 100 and 200 mg/kg of V. officinalis L. hydro-alcoholic extract respectively, during the sensitization protocol. Forced swimming test was performed for all groups and immobility time was recorded. Finally, the animals were placed in the open-field apparatus and the crossing number on peripheral and central areas was observed.
resultsThe immobility time in the sensitized group was higher than that in the control group (P < 0.01). The animals in Sent-Ext 100 and Sent-Ext 200 groups had lower immobility times in comparison with sensitized group (P < 0.05 and P < 0.01). In the open field test, the crossed number in peripheral by the sensitized group was higher than that of the control one (P < 0.01) while, the animals of Sent-Ext 50, Sent-Ext 100 and Sent-Ext 200 groups had lower crossing number in peripheral compared with the sensitized group (P < 0.05 and P < 0.01 respectively). Furthermore, in the sensitized group, the central crossing number was lower than that of the control group (P < 0.001). In the animals treated by 200 mg/kg of the extract, the central crossing number was higher than that of the sensitized group (P < 0. 05).
conclusionsThe results of the present study showed that the hydro-alcoholic extract of V. officinalis prevents depression like behavior in ovalbumin sensitized rats. These results support the traditional belief on the about beneficial effects of V. officinalis in the nervous system. Moreover, further investigations are required in order to better understand this protective effect.
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