ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Frazzled/DCC Regulates Gap Junction Formation at aeNeuro · 2025Article
- SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.Nature communications · 2021Article
- Origins and Evolutionary Patterns of theG3 (Bethesda, Md.) · 2020Article
- Article
- Drosophila Netrin-B controls mushroom body axon extension and regulates courtship-associated learning and memory of a Drosophila fragile X syndrome model.Molecular brain · 2019Article
- Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions.Cold Spring Harbor perspectives in biology · 2018Review
- Innexins: Expression, Regulation, and Functions.Frontiers in physiology · 2018Review
- Fragile X Mental Retardation Protein Restricts Small Dye Iontophoresis Entry into Central Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Myostatin-like proteins regulate synaptic function and neuronal morphology.Development (Cambridge, England) · 2017Article
- Article
- The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.Neural development · 2016Review
- Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.PLoS genetics · 2016Article
- Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster.PloS one · 2016Article
- Engrailed alters the specificity of synaptic connections of Drosophila auditory neurons with the giant fiber.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Netrin and its receptor, Frazzled, dictate the strength of synaptic connections in the giant fiber system (GFS) of Drosophila melanogaster by regulating gap junction localization in the presynaptic terminal. In Netrin mutant animals, the synaptic coupling between a giant interneuron and the "jump" motor neuron was weakened and dye coupling between these two neurons was severely compromised or absent. In cases in which Netrin mutants displayed apparently normal synaptic anatomy, half of the specimens exhibited physiologically defective synapses and dye coupling between the giant fiber (GF) and the motor neuron was reduced or eliminated, suggesting that gap junctions were disrupted in the Netrin mutants. When we examined the gap junctions with antibodies to Shaking-B (ShakB) Innexin, they were significantly decreased or absent in the presynaptic terminal of the mutant GF. Frazzled loss of function mutants exhibited similar defects in synaptic transmission, dye coupling, and gap junction localization. These data are the first to show that Netrin and Frazzled regulate the placement of gap junctions presynaptically at a synapse.
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