Evidence map›Paper›PMID 24740885›Full record

ReviewEuropean heart journal2014

Medial vascular calcification revisited: review and perspectives.

Peter Lanzer, Manfred Boehm, Victor Sorribas, Marc Thiriet, Jan Janzen, Thomas Zeller, Cynthia St Hilaire, Catherine Shanahan

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in European heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05916950 (The THOR IDE Study), which is not on this map. Cited by 367 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
367citing papers in PubMed, 1 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05916950 narecruitingnot on this mapstarted 2024, after this paper: background citation

The THOR IDE Study

TypeinterventionalSponsorPhilips Clinical & Medical Affairs GlobalRan2024 to 2027Enrolled155ConditionsPeripheral Artery Disease, Peripheral Artery Stenosis, Peripheral Artery Calcification, PADArmsThor laser atherectomy
3 · Its place in the literature

Who cites it

367 citing papers in PubMed, 1 synthesis or guideline pooled it, 707 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Observational
  15. Article
  16. Article
  17. Peripheral Vascular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  18. Article
  19. Review
  20. Article

307 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Peter LanzerDivision of Cardiovascular Disease, Department of Internal Medicine, Health Care Center Bitterfeld, Bitterfeld-Wolfen gGmbH, Friedrich-Ludwig-Jahn-Straße 2, D-06749 Bitterfeld-Wolfen, Germany planzer@gzbiwo.de.
Manfred BoehmCenter for Molecular Medicine, National Institutes of Health, Bethesda, MD, USA.
Victor SorribasLaboratory of Molecular Toxicology, University of Zaragoza, Zaragoza, Spain.
Marc ThirietNational Institute for Research in Computer Science and Control, Paris, France.
Jan JanzenVascPath, Bern, Switzerland.
Thomas ZellerUniversity Heart Center Freiburg, Bad Krozingen, Germany.
Cynthia St HilaireCenter for Molecular Medicine, National Institutes of Health, Bethesda, MD, USA.
Catherine ShanahanCardiovascular Division, King's College London, London, UK.
National Institutes of Health · USGesundheitszentrum Bitterfeld · DEKing's College London · GBLaboratoire Jacques-Louis Lions · FRUniversidad de Zaragoza · ESUniversitäts-Herzzentrum Freiburg-Bad Krozingen · DE

Funding

Vascular remodeling in patients with rare genetic disordersZIAHL006077 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BOEHM, MANFRED · 2010 to 2025
$22.9M
British Heart Foundation RG/11/14/29056
6 · The paper itself

Abstract

Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.

Indexed as

AdultArteriosclerosisBiomarkersCalcium-Binding ProteinsDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleHumansHyperphosphatemiaMaleMonckeberg Medial Calcific SclerosisPhosphatesPrognosisRenal Insufficiency, ChronicTerminology as TopicTunica IntimaBiomarkersCalcium-Binding ProteinsPhosphatesMönckeberg's media sclerosisVascular calcificationsVascular functionVascular molecular biology and genetics

Identifiers

PMID24740885
PMCPMC4072893
OpenAlexW2061046080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.