ArticleHuman brain mapping2014
Alterations in amplitude of low frequency fluctuation in treatment-naïve major depressive disorder measured with resting-state fMRI.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Altered Resting-State Functional Activity in Medication-Naive Patients With First-Episode Major Depression Disorder vs. Healthy Control: A Quantitative Meta-Analysis.Frontiers in behavioral neuroscience · 2019Pooled it
- Conjoint and dissociated structural and functional abnormalities in first-episode drug-naive patients with major depressive disorder: a multimodal meta-analysis.Scientific reports · 2017Pooled it
- Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Intervention-induced enhancement in intrinsic brain activity in healthy older adults.Scientific reports · 2014Trial
- Power Spectral Slope as a Novel Brain Functional Marker for Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- A mega-analysis of low frequency resting-state measures in mood and psychosis-spectrum disorders.medRxiv : the preprint server for health sciences · 2025Article
- Alterations of cerebral intrinsic activity in first-episode, drug-naive patients with major depressive disorder.BJPsych open · 2025Article
- Alterations in Cerebral Intrinsic Activity in First-Episode, Drug-Naive Patients With Major Depressive Disorder.Cureus · 2025Article
- Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics data.Translational psychiatry · 2025Article
- Abnormal intrinsic functional hubs and connectivity in patients with post-stroke depression.Annals of clinical and translational neurology · 2024Article
- Aberrant resting-state co-activation network dynamics in major depressive disorder.Translational psychiatry · 2024Article
- In search of a marker of altered cerebrovascular function in hypertension: Analysis of the fractional amplitude of low-frequency fluctuations in UK Biobank resting state fMRI data.Cerebral circulation - cognition and behavior · 2024Article
- Genes associated with spontaneous brain activity changes in clinically different patients with major depressive disorder: A transcription-neuroimaging association study.CNS neuroscience & therapeutics · 2023Article
- Abnormal voxel-mirrored homotopic connectivity in first-episode major depressive disorder using fMRI: a machine learning approach.Frontiers in psychiatry · 2023Article
- Conceptualizing psychological resilience through resting-state functional MRI in a mentally healthy population: a systematic review.Frontiers in behavioral neuroscience · 2023Review
- The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task.Frontiers in psychiatry · 2023Article
- Shared and disease-sensitive dysfunction across bipolar and unipolar disorder during depressive episodes: a transdiagnostic study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Altered Regional Homogeneity and Amplitude of Low-Frequency Fluctuations Induced by Electroconvulsive Therapy for Adolescents with Depression and Suicidal Ideation.Brain sciences · 2022Article
- Changes in the amplitude of low-frequency fluctuations in specific frequency bands in major depressive disorder after electroconvulsive therapy.World journal of psychiatry · 2022Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
There are limited resting-state functional magnetic resonance imaging (fMRI) studies in major depressive disorder (MDD). Of these studies, functional connectivity analyses are mostly used. However, a new method based on the magnitude of low frequency fluctuation (LFF) during resting-state fMRI may provide important insight into MDD. In this study, we examined the amplitude of LFF (ALFF) within the whole brain during resting-state fMRI in 30 treatment-naïve MDD subjects and 30 healthy control (HC) subjects. When compared with HC, MDD subjects showed increased ALFF in the frontal cortex (including the bilateral ventral/dorsal anterior cingulate cortex, orbitofrontal cortex, premotor cortex, ventral prefrontal cortex, left dorsal lateral frontal cortex, left superior frontal cortex), basal ganglia (including the right putamen and left caudate nucleus), left insular cortex, right anterior entorhinal cortex and left inferior parietal cortex, together with decreased ALFF in the bilateral occipital cortex, cerebellum hemisphere, and right superior temporal cortex. These findings may relate to characteristics of MDD, such as excessive self-referential processing and deficits in cognitive control of emotional processing, which may contribute to the persistent and recurrent nature of the disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.