ReviewCurrent neurology and neuroscience reports2014
Understanding essential tremor: progress on the biological front.
Review in Current neurology and neuroscience reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Accurate Tracking of Locomotory Kinematics in Mice Moving Freely in Three-Dimensional Environments.eNeuro · 2025Article
- Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China.Molecular biology reports · 2024Article
- Biological mechanisms of aging predict age-related disease co-occurrence in patients.Aging cell · 2022Article
- Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor.The Journal of clinical investigation · 2020Article
- Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABACerebellum (London, England) · 2020Article
- A pilot study of essential tremor: cerebellar GABA+/Glx ratio is correlated with tremor severity.Cerebellum & ataxias · 2020Article
- IL1B polymorphism is associated with essential tremor in Chinese population.BMC neurology · 2019Article
- Article
- White matter measures correlate with essential tremor severity-A pilot diffusion tensor imaging study.Brain and behavior · 2018Article
- In Vivo Dentate Nucleus Gamma-aminobutyric Acid Concentration in Essential Tremor vs. Controls.Cerebellum (London, England) · 2018Article
- Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures.Parkinsonism & related disorders · 2017Article
- Linking Essential Tremor to the Cerebellum: Neuropathological Evidence.Cerebellum (London, England) · 2016Review
- The Role of β-Carboline Alkaloids in the Pathogenesis of Essential Tremor.Cerebellum (London, England) · 2016Review
- Essential Tremor: A Common Disorder of Purkinje Neurons?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2016Review
- RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions.Biomolecules · 2015Review
- Reduced body mass index in essential tremor: a study of 382 cases and 392 matched controls.European journal of neurology · 2015Article
- Essential tremor: a neurodegenerative disease?Tremor and other hyperkinetic movements (New York, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
For many years, little was written about the underlying biology of ET, despite its high prevalence. Discussions of disease mechanisms were dominated by a focus on tremor physiology. The traditional model of ET, the olivary model, was proposed in the 1970s. The model suffers from several critical problems, and its relevance to ET has been questioned. Recent mechanistic research has focused on the cerebellum. Clinical and neuroimaging studies strongly implicate the importance of this brain region in ET. Recent mechanistic research has been grounded more in tissue-based changes (i.e., postmortem studies of the brain). These studies have collectively and systematically identified a sizable number of changes in the ET cerebellum, and have led to a new model of ET, referred to as the cerebellar degenerative model. Hence, there is a renewed interest in the science behind the biology of ET. How the new understanding of ET will translate into treatment changes is an open question.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.