ArticleCellular and molecular life sciences : CMLS2014
Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia.
Article in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Metallic nanoparticles in precision medicine for gastrointestinal cancers: Diagnostic and therapeutic advances.Journal of pharmaceutical analysis · 2026Review
- Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy.BMC biotechnology · 2024Article
- Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology.Signal transduction and targeted therapy · 2022Review
- Phytochemical-conjugated bio-safe gold nanoparticles in breast cancer: a comprehensive update.Breast cancer (Tokyo, Japan) · 2022Review
- Gold Nanoparticles Contact with Cancer Cell: A Brief Update.International journal of molecular sciences · 2022Review
- Intracellular and extracellular targets as mechanisms of cancer therapy by nanomaterials in relation to their physicochemical properties.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Exploring near-infrared absorbing nanocarriers to overcome cancer drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2020Review
- Adaptive changes induced by noble-metal nanostructuresTheranostics · 2020Review
- Cellular senescence is associated with reorganization of the microtubule cytoskeleton.Cellular and molecular life sciences : CMLS · 2019Article
- Gold nanoparticle uptake is enhanced by estradiol in MCF-7 breast cancer cells.International journal of nanomedicine · 2019Article
- In vitro outlook of gold nanoparticles in photo-thermal therapy: a literature review.Lasers in medical science · 2018Review
- Novel Combination of Silver Nanoparticles and Carbon Nanotubes for Plasmonic Photo Thermal Therapy in Melanoma Cancer Model.Advanced pharmaceutical bulletin · 2018Article
- Toward a systematic exploration of nano-bio interactions.Toxicology and applied pharmacology · 2017Review
- Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics.Scientific reports · 2016Article
- Zinc oxide nanoparticles-induced epigenetic change and G2/M arrest are associated with apoptosis in human epidermal keratinocytes.International journal of nanomedicine · 2016Article
- Super-resolution microscopy reveals a golden kiss of death to mitochondria.Cell death discovery · 2016Article
- Anti-HER2/neu peptide-conjugated iron oxide nanoparticles for targeted delivery of paclitaxel to breast cancer cells.Nanoscale · 2015Article
- Toxicity and Biokinetics of Colloidal Gold Nanoparticles.Nanomaterials (Basel, Switzerland) · 2015Article
- Review
- Gold Nanoparticles Impinge on Nucleoli and the Stress Response in MCF7 Breast Cancer Cells.NanobiomedicineReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Gold nanoparticles have emerged as promising tools for cancer research and therapy, where they can promote thermal killing. The molecular mechanisms underlying these events are not fully understood. The geometry and size of gold nanoparticles can determine the severity of cellular damage. Therefore, small and big gold nanospheres as well as gold nanoflowers were evaluated side-by-side. To obtain quantitative data at the subcellular and molecular level, we assessed how gold nanoparticles, either alone or in combination with mild hyperthermia, altered the physiology of cultured human breast cancer cells. Our analyses focused on the nucleus, because this organelle is essential for cell survival. We showed that all the examined gold nanoparticles associated with nuclei. However, their biological effects were quantitatively different. Thus, depending on the shape and size, gold nanoparticles changed multiple nuclear parameters. They redistributed stress-sensitive regulators of nuclear biology, altered the nuclear morphology, reorganized nuclear laminae and envelopes, and inhibited nucleolar functions. In particular, gold nanoparticles reduced the de novo biosynthesis of RNA in nucleoli, the subnuclear compartments that produce ribosomes. While small gold nanospheres and nanoflowers, but not big gold nanospheres, damaged the nucleus at normal growth temperature, several of these defects were further exacerbated by mild hyperthermia. Taken together, the toxicity of gold nanoparticles correlated with changes in nuclear organization and function. These results emphasize that the cell nucleus is a prominent target for gold nanoparticles of different morphologies. Moreover, we demonstrated that RNA synthesis in nucleoli provides quantitative information on nuclear damage and cancer cell survival.
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