ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
MicroRNA-195 regulates steroid receptor coactivator-3 protein expression in hepatocellular carcinoma cells.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- A meta-analysis of microRNA expression in liver cancer.PloS one · 2014Pooled it
- MicroRNA-195: a review of its role in cancers.OncoTargets and therapy · 2018Review
- The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells.Scientific reports · 2017Article
- miR-195 inhibits cell proliferation via targeting AEG-1 in hepatocellular carcinoma.Oncology letters · 2017Article
- miR-137 inhibits the proliferation of human non-small cell lung cancer cells by targeting SRC3.Oncology letters · 2017Article
- miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis.Oncotarget · 2016Article
- miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets.Molecular and cellular endocrinology · 2015Review
- Roles for miRNAs in endocrine resistance in breast cancer.Endocrine-related cancer · 2015Review
- miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- MiR-141 targets ZEB2 to suppress HCC progression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple studies have shown that steroid receptor coactivator-3 (SRC-3) is upregulated and promotes cell proliferation in several human cancers, including breast, lung, and prostate carcinoma. However, its molecular determinants remain largely unexplored. In the current study, by way of informatics software, we found that MicroRNA-195 (miR-195) could negatively regulate protein levels of SRC-3 through targeting its 3'-untranslated region (3'-UTR) in hepatocellular carcinoma (HCC) cells. As a result, miR-195 mimics inhibited while its antisense enhanced SRC-3 protein levels. Furthermore, miR-195 could modulate cell proliferation and tumor growth in vivo and in vitro. Therefore, our results demonstrate a novel molecular mechanism for the dysregulated expression of SRC-3 in hepatocellular carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.