ArticleBirth defects research. Part A, Clinical and molecular teratology2014
Maternal intake of vitamin E and birth defects, national birth defects prevention study, 1997 to 2005.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis.Orphanet journal of rare diseases · 2018Pooled it
- Maternal Myo-Inositol Intake and Congenital Heart Defects in Offspring: A Population-Based Case-Control Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- [Relationship between micronutrients supplementation during periconceptional period and serum concentration of vitamin E in the 1st trimester of gestational period].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Drug-related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria.Pharmacology research & perspectives · 2019Article
- Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI.Scientific reports · 2017Article
- Genetic and environmental factors in the aetiology of hypospadias.Pediatric surgery international · 2015Review
- Review of evidence for environmental causes of uveal coloboma.Survey of ophthalmologyReview
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundIn a recent study, high maternal periconceptional intake of vitamin E was found to be associated with risk of congenital heart defects (CHDs). To explore this association further, we investigated the association between total daily vitamin E intake and selected birth defects.
methodsWe analyzed data from 4525 controls and 8665 cases from the 1997 to 2005 National Birth Defects Prevention Study. We categorized estimated periconceptional energy-adjusted total daily vitamin E intake from diet and supplements into quartiles (referent, lowest quartile). Associations between quartiles of energy-adjusted vitamin E intake and selected birth defects were adjusted for demographic, lifestyle, and nutritional factors.
resultsWe observed a statistically significant association with the third quartile of vitamin E intake (odds ratio [OR], 1.17; 95% confidence interval [CI], 1.01-1.35) and all CHDs combined. Among CHD sub-types, we observed associations with left ventricular outflow tract obstruction defects, and its sub-type, coarctation of the aorta and the third quartile of vitamin E intake. Among defects other than CHDs, we observed associations between anorectal atresia and the third quartile of vitamin E intake (OR, 1.66; 95% CI, 1.01-2.72) and hypospadias and the fourth quartile of vitamin E intake (OR, 1.42; 95% CI, 1.09-1.87).
conclusionSelected quartiles of energy-adjusted estimated total daily vitamin E intake were associated with selected birth defects. However, because these few associations did not exhibit exposure-response patterns consistent with increasing risk associated with increasing intake of vitamin E, further studies are warranted to corroborate our findings.
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