ArticlePloS one2014
Mismatch negativity latency and cognitive function in schizophrenia.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- Relationships Between Auditory Processing and Cognitive Abilities in Adults: A Systematic Review.Journal of speech, language, and hearing research : JSLHR · 2024Pooled it
- Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia.Schizophrenia research · 2018Pooled it
- Quantitative electroencephalography parameters as neurophysiological biomarkers of schizophrenia-related deficits: A Phase II substudy of patients treated with iclepertin (BI 425809).Translational psychiatry · 2022Trial
- Perturbed sensory memory associated with schizotypy symptom load.Schizophrenia research · 2026Article
- Temporal imprecision and its dynamics in schizophrenia.Translational psychiatry · 2025Article
- Article
- Impact of acute psychosocial stress on attentional control in humans. A study of evoked potentials and pupillary response.Neurobiology of stress · 2023Article
- Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Early Auditory Processing Predicts Efficient Working Memory Functioning in Schizophrenia.Brain sciences · 2022Article
- The phenomenology of auditory verbal hallucinations in schizophrenia and the challenge from pseudohallucinations.Frontiers in psychiatry · 2022Article
- Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis.Journal of psychiatric research · 2021Article
- Differential effects of gender on mismatch negativity to violations of simple and pattern acoustic regularities.Brain and behavior · 2021Article
- Mismatch negativity indices and functional outcomes in unipolar and bipolar depression.Scientific reports · 2020Article
- Mismatch Negativity Occurrence with Verbal and Nonverbal Stimuli in Normal-Hearing Adults.International archives of otorhinolaryngology · 2020Article
- Mismatch Negativity Elicited by Verbal and Nonverbal Stimuli: Comparison with Potential N1.International archives of otorhinolaryngology · 2020Article
- Neurophysiological Biomarkers in Schizophrenia-P50, Mismatch Negativity, and TMS-EMG and TMS-EEG.Frontiers in psychiatry · 2020Review
- Progressive Impairment of Mismatch Negativity Is Reflective of Underlying Pathophysiological Changes in Patients With First-Episode Psychosis.Frontiers in psychiatry · 2020Article
- Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome.Frontiers in psychiatry · 2020Article
- Attenuated mismatch negativity in patients with first-episode antipsychotic-naive schizophrenia using a source-resolved method.NeuroImage. Clinical · 2019Article
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5 authors.
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Abstract
backgroundThe Mismatch Negativity (MMN) is an event-related potential (ERP) sensitive to early auditory deviance detection and has been shown to be reduced in schizophrenia patients. Moreover, MMN amplitude reduction to duration deviant tones was found to be related to functional outcomes particularly, to neuropsychological (working memory and verbal domains) and psychosocial measures. While MMN amplitude is thought to be correlated with deficits of early sensory processing, the functional significance of MMN latency remains unclear so far. The present study focused on the investigation of MMN in relation to neuropsychological function in schizophrenia.
methodForty schizophrenia patients and 16 healthy controls underwent a passive oddball paradigm (2400 binaural tones; 88% standards [1 kHz, 80 db, 80 ms], 11% frequency deviants [1.2 kHz], 11% duration deviants [40 ms]) and a neuropsychological test-battery. Patients were assessed with regard to clinical symptoms.
resultsCompared to healthy controls schizophrenia patients showed diminished MMN amplitude and shorter MMN latency to both deviants as well as an impaired neuropsychological test performance. Severity of positive symptoms was related to decreased MMN amplitude to duration deviants. Furthermore, enhanced verbal memory performance was associated with prolonged MMN latency to frequency deviants in patients.
conclusionThe present study corroborates previous results of a diminished MMN amplitude and its association with positive symptoms in schizophrenia patients. Both, the findings of a shorter latency to duration and frequency deviants and the relationship of the latter with verbal memory in patients, emphasize the relevance of the temporal aspect of early auditory discrimination processing in schizophrenia.
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