ArticlePloS one2014
Acute moderate exercise does not further alter the autonomic nervous system activity in patients with sickle cell anemia.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Nocturnal peripheral vasoconstriction predicts the frequency of severe acute pain episodes in children with sickle cell disease.American journal of hematology · 2021Trial
- Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease.Journal of pediatric hematology/oncology · 2018Trial
- Autonomic and Vascular Responses during Reactive Hyperemia in Healthy Individuals and Patients with Sickle Cell Anemia.Medicina (Kaunas, Lithuania) · 2023Article
- Heart rate variability associated with acute exercise challenge in children with sickle cell anaemia.British journal of haematology · 2022Article
- Objectively measured physical activity levels and sedentary time in children and adolescents with sickle cell anemia.PloS one · 2018Article
- Dexmedetomidine ameliorates nocifensive behavior in humanized sickle cell mice.European journal of pharmacology · 2015Article
- Physical exercise in sickle cell anemia: a systematic review.Hematology, transfusion and cell therapyReview
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (<15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients.
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