ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2014
Comparison of blood loss according to use of aspirin in lumbar fusion patients.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02807441 (Association Between Perioperative Bleeding and Aspirin Use in Spine Surgery), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Perioperative Bleeding and Aspirin Use in Spine Surgery: A Randomized, Controlled Trial
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Aspirin therapy discontinuation and intraoperative blood loss in spinal surgery: a systematic review.Neurosurgical review · 2018Pooled it
- Safety of continuing aspirin therapy during spinal surgery: A systematic review and meta-analysis.Medicine · 2017Pooled it
- Long-term aspirin use and perioperative outcomes in lumbar interbody fusion: a population-based study using US national inpatient sample database.Journal of orthopaedic surgery and research · 2025Article
- Safety of Continuous Low-Dose Aspirin Therapy for Lumbar Decompression Alone.Spine surgery and related research · 2025Article
- Primary Results of Our Protocol for Standardization of Perioperative Antiplatelet Agent Management on the Incidence of Epidural Hematoma and Thrombotic Complications in Posterior Cervical Surgery: A Prospective Cohort Study.Spine surgery and related research · 2024Article
- Impact of Perioperative Acetylsalicylic Acid (ASA) Administration on Postoperative Intracranial Hemorrhage (pICH) and Thromboembolic Events in Patients with Intracranial Meningiomas.Journal of clinical medicine · 2024Article
- The safety of perioperative antiplatelet continuation without selection biases in microsurgical decompression surgery for single level lumbar spinal stenosis and lumbar disc herniotomy.Acta neurochirurgica · 2024Article
- Article
- Management of Antithrombotic Drugs before Elective Spine Surgery: A Nationwide Web-Based Questionnaire Survey in Japan.Spine surgery and related research · 2023Article
- Safety and Clinical Results of Continuous Low-Dose Aspirin in Microendoscopic Laminectomy.Spine surgery and related research · 2023Article
- Risk Factors for Early Mortality in Older Patients with Traumatic Cervical Spine Injuries-A Multicenter Retrospective Study of 1512 Cases.Journal of clinical medicine · 2023Article
- Perioperative myocardial injury after elective neurosurgery: incidence, risk factors, and effects on mortality.Neurosurgical review · 2022Article
- Is Blood Loss Greater in Elderly Patients under Antiplatelet or Anticoagulant Medication for Cervical Spine Injury Surgery? A Japanese Multicenter Survey.Spine surgery and related research · 2022Article
- Nonsteroidal anti-inflammatory drugs (NSAID) do not increase blood loss or the incidence of postoperative epidural hematomas when using minimally invasive fusion techniques in the degenerative lumbar spine.Frontiers in surgery · 2022Article
- Safety of Continuous Low-Dose Aspirin Therapy for Cervical Laminoplasty.Spine surgery and related research · 2022Article
- Perioperative Anticoagulation Management in Spine Surgery: Initial Findings From the AO Spine Anticoagulation Global Survey.Global spine journal · 2020Article
- Anticoagulation and Spine Surgery.Global spine journal · 2020Article
- Unnecessary Cervical Epidural Injection in An Octogenarian.Surgical neurology international · 2019Article
- When to stop anticoagulation, anti-platelet aggregates, and non-steroidal anti-inflammatories (NSAIDs) prior to spine surgery.Surgical neurology international · 2019Article
- Avoiding inappropriate spine surgery in a patient with major cardiac comorbidities.Surgical neurology international · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate and compare blood losses intra and postoperatively between lumbar fusion patients with and without antiplatelet use.
methodsA total of 106 patients who had undergone at least 2 or more segments of lumbar fusion surgery were selected for the study. They were divided into three groups. Group 1 was not on medication before the surgery. Groups 2 and 3 had taken aspirin prior to the surgery. Group 2 discontinued the medication 1 week before the operation, but group 3 continued the use. In addition, non-steroid anti-inflammatory drug (NSAIDs) use in all patients was questioned. Amount of blood losses and platelet function were evaluated.
resultsWhen usage of NSAID was not controlled, intraoperative, postoperative, and total blood losses were found to have no statistical significance among the groups. However, when NSAID usage was taken into account, there were significantly higher blood losses in groups 2 and 3 compared with group 1. The use of NSAID resulted in significantly higher blood loss in group 1, but not in groups 2 or 3. The platelet function test results disclosed statistical differences between groups 1 and 2 and groups 1 and 3.
conclusionAspirin significantly increases the risk of bleeding in patients undergoing lumbar fusion at two or more levels. This risk is present even in patients who discontinued aspirin 1 week prior to surgery. In patients with high risk of complications resulting from aspirin discontinuation, the use should be allowed in lumbar fusion surgery. However, strong attention must be paid to avoid excessive bleeding. Because NSAID use also increases surgical blood loss, proper interval from discontinuation to surgery must be granted to minimize the risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.