ArticlePloS one2014
Maternal prepregancy BMI and lipid profile during early pregnancy are independently associated with offspring's body composition at age 5-6 years: the ABCD study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Addressing obesity in the first 1000 days in high risk infants: Systematic review.Maternal & child nutrition · 2021Pooled it
- The association between maternal body mass index and child obesity: A systematic review and meta-analysis.PLoS medicine · 2019Pooled it
- Physical activity in infancy is associated with body composition at age three.BMC public health · 2026Trial
- Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood.International journal of obesity (2005) · 2023Trial
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- Association between periconceptional weight loss and maternal and neonatal outcomes in obese infertile women.PloS one · 2018Trial
- Environmental Lead (Pb) Exposure Versus Fatty Acid Content in Blood and Milk of the Mother and in the Blood of Newborn Children.Biological trace element research · 2016Trial
- Maternal dyslipidemia in the first trimester and adverse pregnancy and offspring outcomes: based on the Tianjin birth cohort.Lipids in health and disease · 2025Article
- The Impact of Overweight and Obesity on Pregnancy: A Narrative Review of Physiological Consequences, Risks and Challenges in Prenatal Care, and Early Intervention Strategies.Current diabetes reports · 2025Review
- Subtypes of Gestational Diabetes Mellitus Are Differentially Associated With Newborn and Childhood Metabolic Outcomes.Diabetes care · 2025Article
- Maternal lipids in overweight and obesity: implications for pregnancy outcomes and offspring's body composition.Seminars in immunopathology · 2025Review
- Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity.JCI insight · 2024Article
- Article
- Article
- Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring.Frontiers in endocrinology · 2024Review
- Article
- Remodulation Effect ofFoods (Basel, Switzerland) · 2023Article
- Novel Metabolic Subtypes in Pregnant Women and Risk of Early Childhood Obesity in Offspring.JAMA network open · 2023Article
- Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study.BMC medicine · 2023Article
- Maternal and fetal predictors of anthropometry in the first year of life in offspring of women with GDM.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing evidence that disturbances in maternal metabolism and, subsequently, intrauterine conditions affect foetal metabolism. Whether this has metabolic consequences in offspring later in life is not fully elucidated. We investigated whether maternal pre-pregnancy body mass index (pBMI) is associated with offspring's adiposity at age 5-6 years and whether this association is mediated by the mother's lipid profile during early pregnancy.
methodsData were derived from a multi-ethnic birth cohort, the Amsterdam Born Children and their Development (ABCD) study (inclusion 2003-2004). During early gestation mothers completed a questionnaire during pregnancy (pBMI) and random non-fasting blood samples were analysed for total cholesterol (TC), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and total free fatty acids (FFA) in early gestation. At age 5-6 years, child's BMI, waist-to-height-ratio (WHtR) and fat% were assessed.
resultsOnly non-diabetic mothers with at term-born children were included (n = 1727). Of all women, 15.1% were overweight(BMI: 25-29.9 kg/m2) and 4.3% were obese (BMI≥30 kg/m2). After adjustments for confounders, every unit increase in pBMI was linearly associated with various offspring variables: BMI (β 0.10; 95% CI 0.08-0.12), WHtR*100 (β 0.13; 95% CI 0.09-0.17), fat% (β 0.21; 95% CI 0.13-0.29) and increased risk for overweight (OR:1.15; 95% CI 1.10-1.20). No convincing proof for mediation by maternal lipid profile during early gestation was found. Moreover, maternal FFA was associated with the child's fat percentage, BMI and risk for overweight. Maternal ApoB and TC were positively associated with the offspring's fat percentage and maternal TG was positively associated with their children's WHtR.
conclusionsBoth pBMI and maternal lipids during early pregnancy are independently related to offspring adiposity.
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