Evidence map›Paper›PMID 24740086›Full record

ArticleScientific reports2014

Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence.

Katharine C Pike, Shelley A Davis, Samuel A Collins, Jane S A Lucas, Hazel M Inskip, Susan J Wilson, Elin R Thomas, Harris A Wain, Piia H M Keskiväli-Bond, Cyrus Cooper and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Review
  2. Article
  3. Article
  4. How best to capture the respiratory consequences of prematurity?European respiratory review : an official journal of the European Respiratory Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Katharine C Pike1] Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] NIHR Southampton Respiratory Biomedical Research Unit [3].
Shelley A Davis1] Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] Human Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [3].
Samuel A CollinsHuman Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.
Jane S A Lucas1] Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] NIHR Southampton Respiratory Biomedical Research Unit.
Hazel M Inskip1] Human Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Susan J WilsonClinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.
Elin R ThomasHuman Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.
Harris A WainHuman Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.
Piia H M Keskiväli-BondHuman Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.
Cyrus Cooper1] Human Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK [3] Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Keith M Godfrey1] Human Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK [3] Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Christopher TorrensHuman Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.
Graham Roberts1] Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] Human Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [3] NIHR Southampton Respiratory Biomedical Research Unit [4].
John W Holloway1] Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] Human Developmental and Health Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [3].
University of Southampton · GB

Funding

British Heart FoundationMedical Research Council G0400473Medical Research Council G0800766Medical Research Council G0900453Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought in humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses were recorded from offspring bronchial segments. Morphometric analysis of paraffin-embedded lung sections was conducted. In a human mother-child cohort ultrasound measurements of fetal growth were related to bronchial hyperreactivity, measured at age six years using methacholine. Protein-restricted rats' offspring demonstrated greater bronchoconstriction than controls. Airway structure was not altered. Children with lesser abdominal circumference growth during 11-19 weeks' gestation had greater bronchial hyperreactivity than those with more rapid abdominal growth. Imbalanced maternal nutrition during pregnancy results in offspring bronchial hyperreactivity. Prenatal environmental influences might play a comparable role in humans.

Indexed as

Diet, Protein-RestrictedAnimalsBronchiBronchoconstrictor AgentsEmbryo, MammalianEmbryonic DevelopmentFemaleHumansLungModels, AnimalPregnancyPregnancy, AnimalPrenatal Exposure Delayed EffectsRatsBronchoconstrictor Agents

Identifiers

PMID24740086
PMCPMC3989559
OpenAlexW2121258365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.