Evidence map›Paper›PMID 24739951›Full record

ArticlePloS one2014

HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.

Xin Che, Fanglin He, Yuan Deng, Shiqiong Xu, Xianqun Fan, Ping Gu, Zhiliang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. RSC advances · 2026
    Article
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  4. Immune recovery uveitis: a focus review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xin CheDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Fanglin HeDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yuan DengDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Shiqiong XuDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xianqun FanDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Ping GuDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhiliang WangDepartment of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1-associated ocular complications, such as microvasculopathies, can lead to the loss of vision in HIV-1-infected patients. Even in patients under highly active antiretroviral therapy, ocular lesions are unavoidable. Ocular complications have been demonstrated to be closely related to the breakdown of the blood-retinal-barrier (BRB); however, the underlying mechanism is not clear. The data from this study indicated that the HIV-1 Tat protein induced the apoptosis of human retinal microvascular endothelial cells (HRMECs) and retinal pigmen epithelium (RPE) cells, which compose the inner BRB and the outer BRB, respectively. In addition, this study found that the activation of N-methyl-D-aspartate receptors (NMDARs) was involved in the apoptosis of RPE cells, but it caused no changes in HRMECs. Furthermore, both cell types exhibited enhanced expression of Bak, Bax and Cytochrome c. The inhibition of Tat activity protected against the apoptosis induced by NMDAR activation and prevented the dysregulation of Bak, Bax and Cytochrome c, revealing an important role for the mitochondrial pathway in HIV-1 Tat-induced apoptosis. Together, these findings suggest a possible mechanism and may identify a potential therapeutic strategy for HIV-1-associated ocular complications.

Indexed as

Antibodies, NeutralizingApoptosisbcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinBlood-Retinal BarrierCell LineCytochromes cDose-Response Relationship, DrugEndothelial CellsGene Expression RegulationHIV-1HumansMitochondriaModels, BiologicalOrgan SpecificityReceptors, N-Methyl-D-AspartateAntibodies, NeutralizingBAK1 protein, humanBAX protein, humanbcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinCytochromes cReceptors, N-Methyl-D-Aspartatetat Gene Products, Human Immunodeficiency Virus

Identifiers

PMID24739951
PMCPMC3989329
OpenAlexW2087401199

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.