ArticleInternational journal of molecular sciences2014
Expression of S100A6 in rat hippocampus after traumatic brain injury due to lateral head acceleration.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 16 citations in OpenAlex.
- Multifaceted roles of S100A6 in neurological disorders: expression, interaction networks, and clinical implications.Frontiers in pharmacology · 2026Review
- Article
- Relationship of S100 Proteins with Neuroinflammation.Biomolecules · 2025Review
- A New Approach for Exploring Reperfusion Brain Damage in Hypoxic Ischemic Encephalopathy.Molecular neurobiology · 2024Article
- The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential.Biomolecules · 2023Review
- S100A6 Protein-Expression and Function in Norm and Pathology.International journal of molecular sciences · 2023Review
- Article
- S100A6 and Its Brain Ligands in Neurodegenerative Disorders.International journal of molecular sciences · 2020Review
- Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions.Aging and disease · 2019Article
- Traumatic brain injury induces long-lasting changes in immune and regenerative signaling.PloS one · 2019Article
- White matter damage after traumatic brain injury: A role for damage associated molecular patterns.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Stress-Dependent Changes in the CacyBP/SIP Interacting Protein S100A6 in the Mouse Brain.PloS one · 2017Article
- Curcumin upregulates S100 expression and improves regeneration of the sciatic nerve following its complete amputation in mice.Neural regeneration research · 2016Article
- Blood-brain barrier dysfunction following traumatic brain injury.Metabolic brain disease · 2015Review
- Wharton's Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain Injury.Cellular and molecular neurobiology · 2015Article
- Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury.World journal of stem cells · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a rat model of traumatic brain injury (TBI), we investigated changes in cognitive function and S100A6 expression in the hippocampus. TBI-associated changes in this protein have not previously been reported. Rat S100A6 was studied via immunohistochemical staining, Western blot, and reverse transcription-polymerase chain reaction (RT-PCR) after either lateral head acceleration or sham. Reduced levels of S100A6 protein and mRNA were observed 1 h after TBI, followed by gradual increases over 6, 12, 24, and 72 h, and then a return to sham level at 14 day. Morris water maze (MWM) test was used to evaluate animal spatial cognition. TBI- and sham-rats showed an apparent learning curve, expressed as escape latency. Although TBI-rats displayed a relatively poorer cognitive ability than sham-rats, the disparity was not significant early post-injury. Marked cognitive deficits in TBI-rats were observed at 72 h post-injury compared with sham animals. TBI-rats showed decreased times in platform crossing in the daily MWM test; the performance at 72 h post-injury was the worst. In conclusion, a reduction in S100A6 may be one of the early events that lead to secondary cognitive decline after TBI, and its subsequent elevation is tightly linked with cognitive improvement. S100A6 may play important roles in neuronal degeneration and regeneration in TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.