Evidence map›Paper›PMID 24739487›Full record

ArticleBMC anesthesiology2014

Intravenous pretreatment with emulsified isoflurane preconditioning protects kidneys against ischemia/reperfusion injury in rats.

Zhaojun Qin, En Lv, Leyun Zhan, Xiangfei Xing, Jianli Jiang, Min Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhaojun QinDepartment of Anesthesiology, Three Gorges University People's Hospital, Yichang, China, No. 4, Hudi Street, Xiling District, Yichang 443000, Hubei, People's Republic of China.
En LvDepartment of Anesthesiology, Three Gorges University People's Hospital, Yichang, China, No. 4, Hudi Street, Xiling District, Yichang 443000, Hubei, People's Republic of China.
Leyun ZhanDepartment of Anesthesiology, Three Gorges University People's Hospital, Yichang, China, No. 4, Hudi Street, Xiling District, Yichang 443000, Hubei, People's Republic of China.
Xiangfei XingDepartment of Anesthesiology, Three Gorges University People's Hospital, Yichang, China, No. 4, Hudi Street, Xiling District, Yichang 443000, Hubei, People's Republic of China.
Jianli JiangDepartment of Anesthesiology, Three Gorges University People's Hospital, Yichang, China, No. 4, Hudi Street, Xiling District, Yichang 443000, Hubei, People's Republic of China.
Min ZhangDepartment of Anesthesiology, Three Gorges University People's Hospital, Yichang, China, No. 4, Hudi Street, Xiling District, Yichang 443000, Hubei, People's Republic of China.
China Three Gorges University · CNYichang Central People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmulsified isoflurane (EIso) is a novel intravenous general anesthetic, which can provide rapid anesthetic induction and recovery. EIso preconditioning could attenuate heart, lung and liver ischemia/reperfusion (I/R) injury. We tested the hypothesis that intravenous pretreatment with EIso would protect kidneys against I/R injury by inhibiting systemic inflammatory responses and improving renal antioxidative ability.

methodsRATS WERE RANDOMLY DIVIDED INTO THESE SIX GROUPS: sham, I/R, intralipid, 1, 2 or 4 ml/kg EIso. Rats were subjected to 45 min left renal pedicle occlusion followed by 3 h reperfusion after right nephrectomy. Rat were treated with intravenous 8% EIso with 1, 2 or 4 ml/kg, or 30% intralipid with 2 ml/kg for 30 min before ischemia, respectively. After reperfusion, renal functional parameters, serum mediator concentrations and markers of oxidative stress in kidney tissues were determined, and renal histopathological analysis were performed.

resultsSerum creatinine, blood urea nitrogen, cystatin c, tumor necrosis factor-α, interleukin-6, and interleukin-10 concentrations were significantly increased after renal I/R as compared to the sham group. So was renal tissue MDA content and histological scores, but renal tissue SOD activity was decreased. Additionally, severe morphological damages were observed in these study groups. In contrast, 2 or 4 ml/kg EIso reduced serum creatinine, blood urea nitrogen, cystatin c, tumor necrosis factor-α, and interleukin-6 levels, decreased renal tissue MDA content and histological scores, increased serum interleukin-10 level and tissue SOD activity as compared to the I/R, intralipid and 1 ml/kg EIso groups. Renal morphological damages were alleviated after pretreatment of 2 or 4 ml/kg EIso.

conclusionsIntravenous EIso produces preconditioning against renal I/R injury in rats, which might be mediated by attenuating inflammation and increasing antioxidation ability.

Indexed as

AnimalsDisease Models, AnimalDose-Response Relationship, DrugEmulsionsInflammationIschemic PreconditioningIsofluraneKidney DiseasesKidney Function TestsMaleOxidative StressPhospholipidsRatsRats, Sprague-DawleyReperfusion InjurySoybean OilEmulsionsIsofluranePhospholipidsSoybean Oilsoybean oil, phospholipid emulsionSuperoxide DismutaseAcute renal ischemiaEmulsified isofluraneInflammationOxidative stressPreconditioning

Identifiers

PMID24739487
PMCPMC3996162
OpenAlexW1989578042

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.