ArticleBMC plant biology2014
A nuclear-encoded chloroplast protein harboring a single CRM domain plays an important role in the Arabidopsis growth and stress response.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 36 citations in OpenAlex.
- Cold-sensitive chloroplast development: advances from chloroplast ribosome-deficient mutants.Planta · 2026Review
- Chloroplasts and Plant Sustainability: Key Roles and Emerging Insights.International journal of molecular sciences · 2026Review
- Pangenome-wide identification of chloroplast RNA splicing and ribosome maturation (CRM) genes in eight Pyrus genomes indicated their involvement in multiple stresses.Scientific reports · 2026Article
- The Regulatory Roles of RNA-Binding Proteins in Plant Salt Stress Response.Plants (Basel, Switzerland) · 2025Review
- The RiceBiology · 2024Article
- Plant organellar RNA maturation.The Plant cell · 2023Review
- RNA-Binding Proteins: The Key Modulator in Stress Granule Formation and Abiotic Stress Response.Frontiers in plant science · 2022Review
- Plant RNA Binding Proteins as Critical Modulators in Drought, High Salinity, Heat, and Cold Stress Responses: An Updated Overview.International journal of molecular sciences · 2021Review
- Multiple Layers of Regulation on Leaf Senescence: New Advances and Perspectives.Frontiers in plant science · 2021Review
- Roles of Organellar RNA-Binding Proteins in Plant Growth, Development, and Abiotic Stress Responses.International journal of molecular sciences · 2020Review
- The bRPS6-Family Protein RFC3 Prevents Interference by the Splicing Factor CFM3b during Plastid rRNA Biogenesis inPlants (Basel, Switzerland) · 2020Article
- Characterization of the CRM Gene Family and Elucidating the Function of OsCFM2 in Rice.Biomolecules · 2020Article
- A chloroplast-targeted pentatricopeptide repeat protein PPR287 is crucial for chloroplast function and Arabidopsis development.BMC plant biology · 2019Article
- Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance.Plant physiology · 2019Article
- Genetic Loci Associated with Salt Tolerance in Advanced Breeding Populations of Tetraploid Alfalfa Using Genome-Wide Association Studies.The plant genome · 2019Article
- Rice OsRH58, a chloroplast DEAD-box RNA helicase, improves salt or drought stress tolerance in Arabidopsis by affecting chloroplast translation.BMC plant biology · 2019Article
- Organellar Gene Expression and Acclimation of Plants to Environmental Stress.Frontiers in plant science · 2017Review
- Emerging Roles of RNA-Binding Proteins in Plant Growth, Development, and Stress Responses.Molecules and cells · 2016Review
- PPR596 Is Required for nad2 mRNA Splicing and Complex I Biogenesis in Mitochondria of Arabidopsis thaliana.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several chloroplast RNA splicing and ribosome maturation (CRM) domain-containing proteins have been characterized for intron splicing and rRNA processing during chloroplast gene expression, the functional role of a majority of CRM domain proteins in plant growth and development as well as chloroplast RNA metabolism remains largely unknown. Here, we characterized the developmental and stress response roles of a nuclear-encoded chloroplast protein harboring a single CRM domain (At4g39040), designated CFM4, in Arabidopsis thaliana.
resultsAnalysis of CFM4-GFP fusion proteins revealed that CFM4 is localized to chloroplasts. The loss-of-function T-DNA insertion mutants for CFM4 (cfm4) displayed retarded growth and delayed senescence, suggesting that CFM4 plays a role in growth and development of plants under normal growth conditions. In addition, cfm4 mutants showed retarded seed germination and seedling growth under stress conditions. No alteration in the splicing patterns of intron-containing chloroplast genes was observed in the mutant plants, but the processing of 16S and 4.5S rRNAs was abnormal in the mutant plants. Importantly, CFM4 was determined to possess RNA chaperone activity.
conclusionsThese results suggest that the chloroplast-targeted CFM4, one of two Arabidopsis genes encoding a single CRM domain-containing protein, harbors RNA chaperone activity and plays a role in the Arabidopsis growth and stress response by affecting rRNA processing in chloroplasts.
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