ReviewCurrent opinion in infectious diseases2014
Detecting specific infections in children through host responses: a paradigm shift.
Review in Current opinion in infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Concurrent cryptococcal and dengue meningoencephalitis as initial presentation of human immunodeficiency virus infection in a patient from arbovirus-endemic northeastern Brazil: a case report.BMC infectious diseases · 2026Article
- Using the Traditional Ex Vivo Whole Blood Model to Discriminate Bacteria by Their Inducible Host Responses.Biomedicines · 2024Article
- Novel Biomarkers Differentiating Viral from Bacterial Infection in Febrile Children: Future Perspectives for Management in Clinical Praxis.Children (Basel, Switzerland) · 2021Review
- BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R.Bioinformatics (Oxford, England) · 2021Article
- Host-Malaria Parasite Interactions and Impacts on Mutual Evolution.Frontiers in cellular and infection microbiology · 2020Review
- Diagnosing enterovirus meningitis via blood transcriptomics: an alternative for lumbar puncture?Journal of translational medicine · 2019Article
- Viral Bacterial Interactions in Children: Impact on Clinical Outcomes.The Pediatric infectious disease journal · 2019Review
- Investigating Pneumonia Etiology Among Refugees and the Lebanese population (PEARL): A study protocol.Gates open research · 2018Article
- Role of viral infections in the development and exacerbation of asthma in children.The Journal of allergy and clinical immunology · 2017Review
- Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections.Kidney international · 2017Article
- Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection.The Journal of infection · 2017Observational
- Transcriptomics in Human Challenge Models.Frontiers in immunology · 2017Review
- Challenges in the Etiology and Diagnosis of Acute Febrile Illness in Children in Low- and Middle-Income Countries.Journal of the Pediatric Infectious Diseases Society · 2016Review
- Anomaly Detection in Host Signaling Pathways for the Early Prognosis of Acute Infection.PloS one · 2016Article
- The human immune response to tuberculosis and its treatment: a view from the blood.Immunological reviews · 2015Review
- Pre-symptomatic diagnosis and treatment of filovirus diseases.Frontiers in microbiology · 2015Review
- Pathogen-Specific Immune Fingerprints during Acute Infection: The Diagnostic Potential of Human γδ T-Cells.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purpose of reviewThere is a need for improved diagnosis and for optimal classification of patients with infectious diseases. An alternative approach to the pathogen-detection strategy is based on a comprehensive analysis of the host response to the infection. This review focuses on the value of transcriptome analyses of blood leukocytes for the diagnosis and management of patients with infectious diseases. RECENT
findingsInitial studies showed that RNA from blood leukocytes of children with acute viral and bacterial infections carried pathogen-specific transcriptional signatures. Subsequently, transcriptional signatures for several other infections have been described and validated in humans with malaria, dengue, salmonella, melioidosis, respiratory syncytial virus, influenza, tuberculosis, and HIV. In addition, transcriptome analyses represent an invaluable tool to understand disease pathogenesis and to objectively classify patients according to the clinical severity. SUMMARY: Microarray studies have been shown to be highly reproducible using different platforms, and in different patient populations, confirming the value of blood transcriptome analyses to study pathogen-specific host immune responses in the clinical setting. Combining the detection of the pathogen with a comprehensive assessment of the host immune response will provide a new understanding of the correlations between specific causative agents, the host response, and the clinical manifestations of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.