ArticleBiophysical journal2014
A general functional response of cytotoxic T lymphocyte-mediated killing of target cells.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Cytotoxic T Lymphocytes Control Growth of B16 Tumor Cells in Collagen-Fibrin Gels by Cytolytic and Non-Lytic Mechanisms.Viruses · 2023Article
- In silico cancer immunotherapy trials uncover the consequences of therapy-specific response patterns for clinical trial design and outcome.Nature communications · 2023Article
- Mathematical modeling suggests cytotoxic T lymphocytes control growth of B16 tumor cells in collagin-fibrin gels by cytolytic and non-lytic mechanisms.bioRxiv : the preprint server for biology · 2023Article
- Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status.Frontiers in immunology · 2023Article
- Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity.eLife · 2021Article
- Article
- A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery.Journal for immunotherapy of cancer · 2021Article
- Control theory helps to resolve the measles paradox.Royal Society open science · 2021Article
- Evaluation of CD8 T cell killing models with computer simulations of 2-photon imaging experiments.PLoS computational biology · 2020Article
- Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data.PLoS computational biology · 2020Article
- Chimeric Antigen Receptor Based Therapy as a Potential Approach in Autoimmune Diseases: How Close Are We to the Treatment?Frontiers in immunology · 2020Review
- Sequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth.Scientific reports · 2019Article
- Towards multiscale modeling of the CD8Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity.The Journal of experimental medicine · 2019Article
- Accounting for Space—Quantification of Cell-To-Cell Transmission Kinetics Using Virus Dynamics Models.Viruses · 2018Article
- Influenza Virus Infection Model With Density Dependence Supports Biphasic Viral Decay.Frontiers in microbiology · 2018Article
- Agent-based modeling of the interaction between CD8+ T cells and Beta cells in type 1 diabetes.PloS one · 2018Article
- A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.Cell communication and signaling : CCS · 2017Article
- A Sigmoid Functional Response Emerges When Cytotoxic T Lymphocytes Start Killing Fresh Target Cells.Biophysical journal · 2017Article
- Immune Cell Repertoire and Their Mediators in Patients with Acute Myocardial Infarction or Stable Angina Pectoris.International journal of medical sciences · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
Cytotoxic T lymphocytes (CTLs) kill virus-infected cells and tumor cells, and play a critical role in immune protection. Our knowledge of how the CTL killing efficiency varies with CTL and target cell numbers is limited. Here, we simulate a region of lymphoid tissue using a cellular Potts model to characterize the functional response of CTL killing of target cells, and find that the total killing rate saturates both with the CTL and the target cell densities. The relative saturation in CTL and target cell densities is determined by whether a CTL can kill multiple target cells at the same time, and whether a target cell can be killed by many CTLs together. We find that all the studied regimes can be well described by a double-saturation (DS) function with two different saturation constants. We show that this DS model can be mechanistically derived for the cases where target cells are killed by a single CTL. For the other cases, a biological interpretation of the parameters is still possible. Our results imply that this DS function can be used as a tool to predict the cellular interactions in cytotoxicity data.
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