Evidence map›Paper›PMID 24738076›Full record

ReviewBioMed research international2014

Low temperature plasma: a novel focal therapy for localized prostate cancer?

Adam M Hirst, Fiona M Frame, Norman J Maitland, Deborah O'Connell

Abstract readReview
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Applications of Plasma-Activated Water in Dentistry: A Review.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam M HirstDepartment of Physics, York Plasma Institute, University of York, Heslington, York YO10 5DD, UK.
Fiona M FrameYCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
Norman J MaitlandYCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
Deborah O'ConnellDepartment of Physics, York Plasma Institute, University of York, Heslington, York YO10 5DD, UK.

Funding

Wellcome TrustWellcome Trust 097829/Z/11/A
6 · The paper itself

Abstract

Despite considerable advances in recent years for the focal treatment of localized prostate cancer, high recurrence rates and detrimental side effects are still a cause for concern. In this review, we compare current focal therapies to a potentially novel approach for the treatment of early onset prostate cancer: low temperature plasma. The rapidly evolving plasma technology has the potential to deliver a wide range of promising medical applications via the delivery of plasma-induced reactive oxygen and nitrogen species. Studies assessing the effect of low temperature plasma on cell lines and xenografts have demonstrated DNA damage leading to apoptosis and reduction in cell viability. However, there have been no studies on prostate cancer, which is an obvious candidate for this novel therapy. We present here the potential of low temperature plasma as a focal therapy for prostate cancer.

Indexed as

Cold TemperatureCryotherapyPhotochemotherapyApoptosisDNA DamageHumansMaleProstatic NeoplasmsReactive Nitrogen SpeciesReactive Oxygen SpeciesReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID24738076
PMCPMC3971493

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.