ArticleOxidative medicine and cellular longevity2014
The protective effects of Shen-Fu injection on experimental acute pancreatitis in a rat model.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Efficacy and Safety of Shenfu Injection for Severe Pneumonia in the Elderly: A Systematic Review and Meta-Analysis Based on Western and Eastern Medicine.Frontiers in pharmacology · 2022Pooled it
- Article
- Therapeutic Effects of Shenfu Injection in Shock.Chinese journal of integrative medicine · 2023Review
- Granny Smith Apple Extract Lowers Inflammation and Improves Antioxidant Status in L-arginine-induced Exocrine Pancreatic Dysfunction in RatsTurkish journal of pharmaceutical sciences · 2021Article
- Effect of shenfu injection on microcirculation in shock patients: A protocol for systematic review and meta-analysis.Medicine · 2020Article
- Shen fu injection for patients with septic shock: Protocol for an updated systematic review.Medicine · 2019Article
- One compound of saponins from Disocorea zingiberensis protected against experimental acute pancreatitis by preventing mitochondria-mediated necrosis.Scientific reports · 2016Article
- Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- The protective effects of curcumin on experimental acute liver lesion induced by intestinal ischemia-reperfusion through inhibiting the pathway of NF-κB in a rat model.Oxidative medicine and cellular longevity · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn the present study, we investigated the protective effects of Shen-Fu injection (SFI) on a caerulein-induced rat pancreatitis (AP) model.
methodsSFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies.
resultsOur results showed that AP caused significant decrease in tissue glutathione (GSH) and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA) and myeloperoxidase (MPO) were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein.
conclusionOur findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB) activity.
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