ArticleBiomicrofluidics2014
High-throughput particle separation and concentration using spiral inertial filtration.
Article in Biomicrofluidics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A Universal and Single-Step (De)Molding Sorting Chip Integrating Inertial and Deterministic Lateral Displacement Units.Bioengineering (Basel, Switzerland) · 2025Article
- Dean-Flow Affected Lateral Focusing and Separation of Particles and Cells in Periodically Inhomogeneous Microfluidic Channels.Sensors (Basel, Switzerland) · 2023Article
- Geometry-Dependent Efficiency of Dean-Flow Affected Lateral Particle Focusing and Separation in Periodically Inhomogeneous Microfluidic Channels.Sensors (Basel, Switzerland) · 2022Article
- Plasma Isolation in a Syringe by Conformal Integration of Inertial Microfluidics.Annals of biomedical engineering · 2021Article
- High-Throughput White Blood Cell (Leukocyte) Enrichment from Whole Blood Using Hydrodynamic and Inertial Forces.Micromachines · 2020Article
- Microfluidic cell concentrator with a reduced-deviation-flow herringbone structure.Biomicrofluidics · 2017Article
- Rapid isolation of blood plasma using a cascaded inertial microfluidic device.Biomicrofluidics · 2017Article
- Enhancement of microfluidic particle separation using cross-flow filters with hydrodynamic focusing.Biomicrofluidics · 2016Article
- Hybrid capillary-inserted microfluidic device for sheathless particle focusing and separation in viscoelastic flow.Biomicrofluidics · 2015Article
- Continuous Flow Microfluidic Bioparticle Concentrator.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A spiral inertial filtration (SIFT) device that is capable of high-throughput (1 ml/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude is reported. This device is able to remove large fractions of sample fluid from a microchannel without disruption of concentrated particle streams by taking advantage of particle focusing in inertial spiral microfluidics, which is achieved by balancing inertial lift forces and Dean drag forces. To enable the calculation of channel geometries in the SIFT microsystem for specific concentration factors, an equivalent circuit model was developed and experimentally validated. Large particle concentration factors were then achieved by maintaining either the average fluid velocity or the Dean number throughout the entire length of the channel during the incremental removal of sample fluid. The SIFT device was able to separate MCF7 cells spiked into whole blood from the non-target white blood cells (WBC) with a recovery of nearly 100% while removing 93% of the sample volume, which resulted in a concentration enhancement of the MCF7 cancer cells by a factor of 14.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.