Evidence map›Paper›PMID 24737969›Full record

ArticleTheScientificWorldJournal2014

In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system.

Dena Dorniani, Aminu Umar Kura, Samer Hasan Hussein-Al-Ali, Mohd Zobir Bin Hussein, Sharida Fakurazi, Abdul Halim Shaari, Zalinah Ahmad

Open access · goldAbstract read
In one paragraph

Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dena DornianiMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400, Selangor, Malaysia.ORCID 0000-0001-5414-9204
Aminu Umar KuraVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, Malaysia.
Samer Hasan Hussein-Al-AliLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Selangor, Malaysia.
Mohd Zobir Bin HusseinMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400, Selangor, Malaysia.
Sharida FakuraziVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, Malaysia.
Abdul Halim ShaariPhysics Department, Faculty of Science, Universiti Putra Malaysia, 43400, Selangor, Malaysia.
Zalinah AhmadVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400, Selangor, Malaysia ; Chemical Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Selangor, Malaysia.
Universiti Putra Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively. Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics. Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG.

Indexed as

AdsorptionCell LineCell SurvivalCoated Materials, BiocompatibleDelayed-Action PreparationsDiffusionGallic AcidHumansIn Vitro TechniquesMagnetite NanoparticlesMaterials TestingNanocapsulesPolyethylene GlycolsPolyvinyl AlcoholCoated Materials, BiocompatibleDelayed-Action PreparationsGallic AcidMagnetite NanoparticlesNanocapsulesPolyethylene GlycolsPolyvinyl Alcohol

Identifiers

PMID24737969
PMCPMC3967779
OpenAlexW2023813768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.