Evidence map›Paper›PMID 24737925›Full record

ArticleMediators of inflammation2014

The time profile of Pentraxin 3 in patients with acute ST-elevation myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention.

Ragnhild Helseth, Svein Solheim, Trine Opstad, Pavel Hoffmann, Harald Arnesen, Ingebjørg Seljeflot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  8. Pentraxin 3 in Cardiovascular Disease.Frontiers in immunology · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ragnhild HelsethDepartment of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway ; Faculty of Medicine, University of Oslo, P.O. Box 1078, Blindern, 0316 Oslo, Norway.ORCID 0000-0001-5012-9214
Svein SolheimDepartment of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway.
Trine OpstadDepartment of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway ; Faculty of Medicine, University of Oslo, P.O. Box 1078, Blindern, 0316 Oslo, Norway.
Pavel HoffmannSection for Interventional Cardiology, Department of Cardiology, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway.ORCID 0000-0003-1287-9174
Harald ArnesenDepartment of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway ; Faculty of Medicine, University of Oslo, P.O. Box 1078, Blindern, 0316 Oslo, Norway.
Ingebjørg SeljeflotDepartment of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway ; Faculty of Medicine, University of Oslo, P.O. Box 1078, Blindern, 0316 Oslo, Norway.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh levels of Pentraxin 3 (PTX3) are reported in acute myocardial infarction (AMI).

aimTo investigate circulating levels and gene expression of PTX3 in patients with AMI and stable angina pectoris (AP) undergoing PCI.

methodsTen patients with AP and 20 patients with AMI were included. Blood samples were drawn before PCI in the AP group and after 3 and 12 hours and days 1, 3, 5, 7, and 14 in both groups.

resultsCirculating PTX3 levels were higher in AMI compared to AP at 3 and 12 hours (P < 0.001 and P = 0.003). Within the AMI group, reduction from 3 hours to all later time points was observed (all P ≤ 0.001). Within the AP group, increase from baseline to 3 hours (P = 0.022), followed by reductions thereafter (all P < 0.05), was observed. PTX3 mRNA increased in the AMI group from 3 hours to days 7 and 14 in a relative manner of 62% and 73%, while a relative reduction from baseline to 3 and 12 hours of 29% and 37% was seen in the AP group.

conclusionHigh circulating PTX3 levels shortly after PCI in AMI indicate that AMI itself influences PTX3 levels. PTX3 mRNA might be in response to fluctuations in circulating levels.

Indexed as

Gene Expression RegulationPercutaneous Coronary InterventionAdultAgedAngina PectorisBlood Cell CountC-Reactive ProteinFemaleHumansLeukocytesMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionPentraxinsRNA, MessengerC-Reactive ProteinPentraxinsRNA, MessengerSerum Amyloid P-ComponentTroponin T

Identifiers

PMID24737925
PMCPMC3967811
OpenAlexW1969569787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.