ArticleLearning & memory (Cold Spring Harbor, N.Y.)2014
Early-life cocaine interferes with BDNF-mediated behavioral plasticity.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- The effects of cocaine exposure in adolescence: Behavioural effects and neuroplastic mechanisms in experimental models.British journal of pharmacology · 2022Review
- Single Exposure to the Cathinones MDPV and α-PVP Alters Molecular Markers of Neuroplasticity in the Adult Mouse Brain.International journal of molecular sciences · 2021Article
- Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal-directed action: A brief review.Journal of neuroscience research · 2020Review
- Defining the place of habit in substance use disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents.Biological psychiatry · 2018Review
- Bidirectional coordination of actions and habits by TrkB in mice.Scientific reports · 2018Article
- Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine.Nature communications · 2017Article
- Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure.PLoS biology · 2017Article
- Connections of the Mouse Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by Brain-Derived Neurotrophic Factor.Biological psychiatry · 2017Article
- Contingent and non-contingent recreational-like exposure to ethanol alters BDNF expression and signaling in the cortico-accumbal network differently.Psychopharmacology · 2016Article
- Adolescent cocaine self-administration induces habit behavior in adulthood: sex differences and structural consequences.Translational psychiatry · 2016Article
- Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors.Neurobiology of disease · 2016Review
- Role of the Perigenual Anterior Cingulate and Orbitofrontal Cortex in Contingency Learning in the Marmoset.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Strain commonalities and differences in response-outcome decision making in mice.Neurobiology of learning and memory · 2016Article
- Going and stopping: Dichotomies in behavioral control by the prefrontal cortex.Nature neuroscience · 2016Article
- Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure.Traffic (Copenhagen, Denmark) · 2015Review
- Adolescent-onset GABAA α1 silencing regulates reward-related decision making.The European journal of neuroscience · 2015Article
- GABAAα1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors.Frontiers in pharmacology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited-or "habitual"-qualities that are resistant to change. We show that selective knockdown of prelimbic prefrontal cortical Brain-derived neurotrophic factor (Bdnf) increases sensitivity to response-outcome associations, blocking habit-like behavioral inflexibility. A history of adolescent cocaine exposure, however, occludes the "beneficial" effects of Bdnf knockdown. This finding highlights a challenge in treating addiction-that drugs of abuse may bias decision-making toward habit systems even in individuals with putative neurobiological resiliencies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.