ReviewExperimental biology and medicine (Maywood, N.J.)2014
Microphysiological modeling of the reproductive tract: a fertile endeavor.
Review in Experimental biology and medicine (Maywood, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- 3D bioprinting technology innovation in female reproductive system.Materials today. Bio · 2025Review
- Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature.Smart medicine · 2023Article
- Organ-on-a-chip technology for the study of the female reproductive system.Advanced drug delivery reviews · 2021Review
- Microphysiological Modeling of the Human Endometrium.Tissue engineering. Part A · 2020Article
- Organoid technology in female reproductive biomedicine.Reproductive biology and endocrinology : RB&E · 2020Review
- Proteomic analyses of decellularized porcine ovaries identified new matrisome proteins and spatial differences across and within ovarian compartments.Scientific reports · 2019Article
- Lessons from bioengineering the ovarian follicle: a personal perspective.Reproduction (Cambridge, England) · 2019Review
- Organs-On-Chip Models of the Female Reproductive System.Bioengineering (Basel, Switzerland) · 2019Review
- Investigation of Each Society for Fertility Preservation in Asia.Frontiers in endocrinology · 2019Review
- Microphysiologic systems in female reproductive biology.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Circadian hormone control in a human-on-a-chip: In vitro biology's ignored component?Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Programming microphysiological systems for children's health protection.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Organs-on-chips: Progress, challenges, and future directions.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Tissue chips - innovative tools for drug development and disease modeling.Lab on a chip · 2017Review
- Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium.Annals of biomedical engineering · 2017Article
- A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.Nature communications · 2017Article
- Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models.Reproductive toxicology (Elmsford, N.Y.) · 2017Review
- Biology coming full circle: joining the whole and the parts.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- The relevance and potential roles of microphysiological systems in biology and medicine.Experimental biology and medicine (Maywood, N.J.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Preclinical toxicity testing in animal models is a cornerstone of the drug development process, yet it is often unable to predict adverse effects and tolerability issues in human subjects. Species-specific responses to investigational drugs have led researchers to utilize human tissues and cells to better estimate human toxicity. Unfortunately, human cell-derived models are imperfect because toxicity is assessed in isolation, removed from the normal physiologic microenvironment. Microphysiological modeling often referred to as 'organ-on-a-chip' or 'human-on-a-chip' places human tissue into a microfluidic system that mimics the complexity of human in vivo physiology, thereby allowing for toxicity testing on several cell types, tissues, and organs within a more biologically relevant environment. Here we describe important concepts when developing a repro-on-a-chip model. The development of female and male reproductive microfluidic systems is critical to sex-based in vitro toxicity and drug testing. This review addresses the biological and physiological aspects of the male and female reproductive systems in vivo and what should be considered when designing a microphysiological human-on-a-chip model. Additionally, interactions between the reproductive tract and other systems are explored, focusing on the impact of factors and hormones produced by the reproductive tract and disease pathophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.