Evidence map›Paper›PMID 24737669›Full record

Trial reportPsycho-oncology2015

Testing the differential effects of symptom management interventions in cancer.

Alla Sikorskii, Charles W Given, Azfar-E-Alam Siddiqi, Victoria Champion, Ruth McCorkle, Sandra L Spoelstra, Barbara A Given

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Psycho-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Self-management education interventions for patients with cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Pooled it
  2. Pooled it
  3. Trial
  4. A sequential multiple assignment randomized trial of symptom management for cancer survivors during treatment and their informal caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alla SikorskiiDepartment of Statistics and Probability, Michigan State University, East Lansing, MI, USA.
Charles W Given
Azfar-E-Alam Siddiqi
Victoria Champion
Ruth McCorkle
Sandra L Spoelstra
Barbara A Given
Michigan State University · USIndiana University – Purdue University Indianapolis · USYale University · US

Funding

Family Home Care for Cancer-Community Based ModelR01CA079280 · NCI · MICHIGAN STATE UNIVERSITY · PI GIVEN, BARBARA ANN · 1998 to 2006
$3.8M
Automated Telephone Monitoring for Symptom ManagementR01CA030724 · NCI · MICHIGAN STATE UNIVERSITY · PI GIVEN, CHARLES W · 2003 to 2008
$3.8M
NCI NIH HHS CA030724NCI NIH HHS CA79280NCI NIH HHS R01 CA030724NCI NIH HHS R01 CA079280
6 · The paper itself

Abstract

objectiveThe purpose of this study was to test for moderating effects of patient characteristics on self-management interventions developed to address symptoms during cancer treatment. Patient's age, education, and depressive symptomatology were considered as potential moderators.

methodsA secondary analysis of data of 782 patients from two randomized clinical trials was performed. Both trials enrolled patients with solid tumors undergoing chemotherapy. After completing baseline interviews, patients were randomized to a nurse-delivered intervention versus intervention delivered by a 'coach' in trial I and to a nurse-delivered intervention versus an intervention delivered by an automated voice response system in trial II. In each of the two trials, following a six-contact 8-week intervention, patients were interviewed at week 10 to assess the primary outcome of symptom severity.

resultsAlthough nurse-delivered intervention proved no better than the coach or automated system in lowering symptom severity, important differences in the intervention by age were found in both trials. Patients aged ≤45 years responded better to the coach or automated system, whereas those aged ≥75 years favored the nurse. Education and depressive symptomatology did not modify the intervention effects in either of the two trials. Depressive symptomatology had a significant main effect on symptom severity at week 10 in both trials (p = 0.03 and p < 0.01, respectively). Education was not associated with symptom severity over and above age and depressive symptomatology.

conclusionsClinicians need to carefully consider the age of the population when using or testing interventions to manage symptoms among cancer patients.

Indexed as

Patient PreferenceAdultAgedAge FactorsAnxietyCognitive Behavioral TherapyDepressionFatigueFemaleGastrointestinal DiseasesHumansMaleMiddle AgedNeoplasmsOncology NursingPatient Education as Topicagecancerdepressionmoderatorsoncologysymptom management

Identifiers

PMID24737669
PMCPMC4198507
OpenAlexW1561129620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.