ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06829290 (Influence of Sarcopenia on the Course of the Diseases - Measured Using Ultrasound and Biochemical Markers), which is not on this map. Cited by 188 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Sarcopenia on the Course of the Diseases - Measured Using Ultrasound and Biochemical Markers
Who cites it
188 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between muscle mass and change in physical functioning in older adults: a systematic review and meta-analysis of prospective studies.European geriatric medicine · 2025Pooled it
- Denosumab for Primary Osteoporosis and Its Impact on Sarcopenia in the Chinese Population: Insights from Clinical Evidence and RANKL Pathway Mendelian Randomization.Clinical interventions in aging · 2025Trial
- Establishment and evaluation of a novel practical tool for the diagnosis of pre-sarcopenia in young people with diabetes mellitus.Journal of translational medicine · 2023Trial
- Circulating Interleukin-6 Is Associated with Skeletal Muscle Strength, Quality, and Functional Adaptation with Exercise Training in Mobility-Limited Older Adults.The Journal of frailty & aging · 2020Trial
- Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL): Effects on Bone Structure and Architecture.Contemporary clinical trials · 2018Trial
- Weight bearing exercise can elicit similar peak muscle activation as medium-high intensity resistance exercise in elderly women.European journal of applied physiology · 2018Trial
- Creatine ( methyl-dJournal of applied physiology (Bethesda, Md. : 1985) · 2018Trial
- Osteosarcopenia: More Than the Sum of Its Parts? A Community-Based Study Across Sarcopenia Definitions.Calcified tissue international · 2026Article
- Prognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation.European geriatric medicine · 2026Article
- Long-term intake of statins or renin-angiotensin system inhibitors: associations with sarcopenia-related parameters in older people.GeroScience · 2026Article
- Development of a sarcopenia identification model for older adults with multimorbidity in Xinjiang communities, Northwest China: a cross-sectional study.BMC geriatrics · 2026Article
- Beyond Handgrip: Associations Between Trunk Strength, Gait Speed, Resting Metabolic Rate, and Muscle Mass in Brazilian Older Women with Probable Sarcopenia.International journal of environmental research and public health · 2026Article
- A Pragmatic Two-Step Screening Algorithm for Sarcopenia and Frailty in Community-Dwelling Older Adults: A Cross-Sectional Population-Based Study.Life (Basel, Switzerland) · 2026Article
- Association between the ratio of uric acid to high-density lipoprotein cholesterol (UHR) and the abnormal risk of sarcopenia: Evidence from two large population-based surveys and interpretable machine learning-driven sarcopenia screening.Therapeutic advances in endocrinology and metabolism · 2026Article
- Association between CVAI-defined body composition phenotypes and prediabetes outcomes in Chinese adults undergoing health check-ups: a cross-sectional study.Frontiers in nutrition · 2026Article
- Associations between walk ratio and osteoporosis and sarcopenia in community-dwelling older women.Physical activity and nutrition · 2025Article
- Role of Branched-Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models.Journal of cachexia, sarcopenia and muscle · 2025Article
- The association between eight dietary factors and sarcopenia: evidence from NHANES data.Journal of health, population, and nutrition · 2025Article
- Muscle mass adjustment for body size: is using a ratio doing the job? A cross-sectional study in two samples of older adults.European geriatric medicine · 2025Article
- Research progress on evaluation methods for skeletal muscle mass assessment in sarcopenia (Review).Oncology letters · 2025Review
128 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundLow lean mass is potentially clinically important in older persons, but criteria have not been empirically validated. As part of the FNIH (Foundation for the National Institutes of Health) Sarcopenia Project, this analysis sought to identify cutpoints in lean mass by dual-energy x-ray absorptiometry that discriminate the presence or absence of weakness (defined in a previous report in the series as grip strength <26kg in men and <16kg in women).
methodsIn pooled cross-sectional data stratified by sex (7,582 men and 3,688 women), classification and regression tree (CART) analysis was used to derive cutpoints for appendicular lean body mass (ALM) that best discriminated the presence or absence of weakness. Mixed-effects logistic regression was used to quantify the strength of the association between lean mass category and weakness.
resultsIn primary analyses, CART models identified cutpoints for low lean mass (ALM <19.75kg in men and <15.02kg in women). Sensitivity analyses using ALM divided by body mass index (BMI: ALMBMI) identified a secondary definition (ALMBMI <0.789 in men and ALMBMI <0.512 in women). As expected, after accounting for study and age, low lean mass (compared with higher lean mass) was associated with weakness by both the primary (men, odds ratio [OR]: 6.9 [95% CI: 5.4, 8.9]; women, OR: 3.6 [95% CI: 2.9, 4.3]) and secondary definitions (men, OR: 4.3 [95% CI: 3.4, 5.5]; women, OR: 2.2 [95% CI: 1.8, 2.8]).
conclusionsALM cutpoints derived from a large, diverse sample of older adults identified lean mass thresholds below which older adults had a higher likelihood of weakness.
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Registered trials
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