ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Grip strength cutpoints for the identification of clinically relevant weakness.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03500393 (A Remotely Supervised Exercise Program for Lung Cancer Patients Undergoing Chemoradiation), which is not on this map. Cited by 281 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Remotely Supervised Exercise Program for Lung Cancer Patients Undergoing Chemoradiation
Who cites it
281 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions.Journal of sport and health science · 2025Pooled it
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Differential Effects of Twice vs. Four Times Weekly Combined Exercise Training in Aging Adults With Hypertension: A Randomized Clinical Trial.Scandinavian journal of medicine & science in sports · 2026Trial
- Cognitive, functional and affective effects of a multi-task training in nursing home residents: results from a randomized pilot study.Aging clinical and experimental research · 2026Trial
- Effects of hearing intervention on physical function: A secondary analysis of the ACHIEVE study.PloS one · 2026Trial
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- Denosumab for osteoporosis in older adults in long-term care: A randomized trial.Journal of the American Geriatrics Society · 2025Trial
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- Associations Between Blood Concentrations of Sex Hormones and Physical Function in Community-Dwelling Older Women: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Trial
- Comparing Prevalence of Sarcopenia Using Twelve Sarcopenia Definitions in a Large Multinational European Population of Community-Dwelling Older Adults.The journal of nutrition, health & aging · 2023Trial
- Ischemic Preconditioning Improves Handgrip Strength and Functional Capacity in Active Elderly Women.International journal of environmental research and public health · 2022Trial
- Can Muscle Mass Be Maintained with A Simple Resistance Intervention in the Older People? A Cluster Randomized Controlled Trial in Thailand.International journal of environmental research and public health · 2021Trial
- An Intervention to Improve Physical Function and Caregiver Perceptions in Family Caregivers of Persons With Heart Failure.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2020Trial
- Validating the Capability for Measuring Age-Related Changes in Grip-Force Strength Using a Digital Hand-Held Dynamometer in Healthy Young and Elderly Adults.BioMed research international · 2020Trial
- Investigation of Differences in the Firing Patterns of Paraspinal Muscle Electromyography in Healthy Subjects.Spine surgery and related research · 2026Article
- Sex-specific handgrip strength thresholds for short-term mortality risk stratification in Mexican older adults: derivation in MHAS and validation in Mex-Cog.European geriatric medicine · 2026Article
- Examining the relationship between D3Cr muscle mass, physical performance, and functional limitation in postmenopausal women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Does the Combination of Abdominal Obesity and Vitamin D Deficiency Increase the Risk of Death in Individuals Aged 50 or Older? Evidence From the ELSA Study.Diabetes, obesity & metabolism · 2026Article
- Physical Function Decline Among Adults With Moderate-to-Severe CKD.Kidney international reports · 2026Article
221 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundWeakness is common and contributes to disability, but no consensus exists regarding a strength cutpoint to identify persons at high risk. This analysis, conducted as part of the Foundation for the National Institutes of Health Sarcopenia Project, sought to identify cutpoints that distinguish weakness associated with mobility impairment, defined as gait speed less than 0.8 m/s.
methodsIn pooled cross-sectional data (9,897 men and 10,950 women), Classification and Regression Tree analysis was used to derive cutpoints for grip strength associated with mobility impairment.
resultsIn men, a grip strength of 26-32 kg was classified as "intermediate" and less than 26 kg as "weak"; 11% of men were intermediate and 5% were weak. Compared with men with normal strength, odds ratios for mobility impairment were 3.63 (95% CI: 3.01-4.38) and 7.62 (95% CI 6.13-9.49), respectively. In women, a grip strength of 16-20 kg was classified as "intermediate" and less than 16 kg as "weak"; 25% of women were intermediate and 18% were weak. Compared with women with normal strength, odds ratios for mobility impairment were 2.44 (95% CI 2.20-2.71) and 4.42 (95% CI 3.94-4.97), respectively. Weakness based on these cutpoints was associated with mobility impairment across subgroups based on age, body mass index, height, and disease status. Notably, in women, grip strength divided by body mass index provided better fit relative to grip strength alone, but fit was not sufficiently improved to merit different measures by gender and use of a more complex measure.
conclusionsCutpoints for weakness derived from this large, diverse sample of older adults may be useful to identify populations who may benefit from interventions to improve muscle strength and function.
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