ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 1,324 papers, 13 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Measuring the Loss of Skeletal Muscle Mass in the Hospitalized Patient With the Diagnosis of COVID-19
Evaluation of a Diagnostic Method: Calf Circumference Versus X-ray Absorptiometry in the Diagnosis of Sarcopenia in Elderly Hospitalized Participants
Evaluating Resistance Training for Sarcopenia in Older Patients With Type 2 Diabetes: Treatment Outcomes
Investigation of Sarcopenia Severity in Patients With Parkinson's Disease
Branched-chain Amino Acids to Improve Sarcopenia in Patients With Advanced Chronic Kidney Disease (BOOST-CKD)
Evaluation of Cancer Cachexia and Analysis of Gut Microbiota in Patients With Breast Cancer Receiving Home Care
Who cites it
1,324 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Does osteosarcopenia synergistically increase risk for incident falls and fractures? A systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Outcomes in clinical trials on sarcopenia: a systematic review and meta-analysis.The journal of nutrition, health & aging · 2026Pooled it
- Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies.British journal of sports medicine · 2026Pooled it
- Comparative efficacy of different interventions on circulating factors in sarcopenia individuals: a systematic review and network meta-analysis.Aging clinical and experimental research · 2026Pooled it
- Vitamin D and resveratrol in sarcopenic obesity: a systematic review highlighting the gap in phenotype-defined randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Pooled it
- Prevalence and Factors Associated with Sarcopenia in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Gerontology · 2026Pooled it
- Assessment tools for patients with stroke-related sarcopenia: a scoping review.Frontiers in medicine · 2026Pooled it
- Associations of sarcopenia and sarcopenic obesity with hypertension: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- High prevalence and multifactorial risks of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- People with heart failure, sarcopenia and chagas disease: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Defining Reference Values for Skeletal Muscle Metrics on Abdominal CT Using Data From Healthy Young Adult Populations: A Systematic Review and Meta-Analysis.AJR. American journal of roentgenology · 2025Pooled it
- Association between sarcopenia and postoperative delirium in elderly surgical patients: a systematic review and meta-analysis.BMC geriatrics · 2025Pooled it
- Sarcopenia Is Associated With Severe Treatment Toxicity and Mortality in Older Adults With Advanced Cancer: A Secondary Analysis.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Postinactivity Exercise Training Improves Sarcopenia Traits in 40-60-Year-Old Women Regardless of Fortified Milk Supplementation.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Effect of a 16-Week Exercise Program After Bariatric Surgery on Sarcopenia Parameters Based on FNIH, EWGSOP2, and EASO/ESPEN Criteria: the Results of the EXPOBAR Randomized Trial Program.Obesity surgery · 2025Trial
- Comparison of muscle strength and power in the short physical performance battery for predicting negative outcomes in older adults with mobility limitations.The journal of nutrition, health & aging · 2025Trial
- Telomere length and appendicular lean mass over six years in older adults with overweight or obesity and metabolic syndrome: a prospective cohort study.GeroScience · 2026Article
- The multiple composite risk index estimates the risks of sarcopenia and comorbidities: unveiling the role of oxidative balance score.Annals of medicine · 2026Article
- Cardiometabolic index (CMI) and sarcopenia as predictors of all-cause and cardiovascular mortality in chronic kidney disease: a NHANES-based cohort study.Renal failure · 2026Article
1,264 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors.
Funding
Abstract
backgroundLow muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for diagnosis should be based on clinically relevant thresholds and independently validated. The Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project used an evidence-based approach to develop these criteria. Initial findings were presented at a conference in May 2012, which generated recommendations that guided additional analyses to determine final recommended criteria. Details of the Project and its findings are presented in four accompanying manuscripts.
methodsThe Foundation for the National Institutes of Health Sarcopenia Project used data from nine sources of community-dwelling older persons: Age, Gene/Environment Susceptibility-Reykjavik Study, Boston Puerto Rican Health Study, a series of six clinical trials, Framingham Heart Study, Health, Aging, and Body Composition, Invecchiare in Chianti, Osteoporotic Fractures in Men Study, Rancho Bernardo Study, and Study of Osteoporotic Fractures. Feedback from conference attendees was obtained via surveys and breakout groups.
resultsThe pooled sample included 26,625 participants (57% women, mean age in men 75.2 [±6.1 SD] and in women 78.6 [±5.9] years). Conference attendees emphasized the importance of evaluating the influence of body mass on cutpoints. Based on the analyses presented in this series, the final recommended cutpoints for weakness are grip strength <26kg for men and <16kg for women, and for low lean mass, appendicular lean mass adjusted for body mass index <0.789 for men and <0.512 for women.
conclusionsThese evidence-based cutpoints, based on a large and diverse population, may help identify participants for clinical trials and should be evaluated among populations with high rates of functional limitations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.