ArticleInternational orthopaedics2014
Is there an association between periprosthetic joint infection and low vitamin D levels?
Article in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04229368 (Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Surgical treatment of infected shoulder arthroplasty. A systematic review.International orthopaedics · 2017Pooled it
- Trial
- Article
- Effect of Vitamin D Supplementation on Total Knee Arthroplasty Outcomes: A Systematic Review.Orthopaedic journal of sports medicine · 2026Review
- Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026Review
- Association of Vitamin D Deficiency With Adverse Postoperative Outcomes Following Hallux Valgus Correction.Foot & ankle orthopaedics · 2026Article
- Review
- The role of vitamin D in shoulder health: a comprehensive review of its impact on rotator cuff tears and surgical results.Clinics in shoulder and elbow · 2025Article
- Preventive strategies to reduce the rate of periprosthetic infections in total joint arthroplasty; a comprehensive review.Archives of orthopaedic and trauma surgery · 2024Review
- Malnutrition in total joint arthroplasty: what should the orthopaedic surgeon consider?EFORT open reviews · 2024Review
- Increased Early Postoperative Complication Rate after Osteoporotic Hip Fracture in Patients with Low 25 (OH) Vitamin D Levels.Nutrients · 2024Observational
- The effect of vitamin D insufficiency on outcomes and complication rates after shoulder arthroplasty: a single center retrospective examination.Seminars in arthroplasty · 2024Article
- Vitamin D-Dependent Rickets Type 1A in Two Siblings with a HypomorphicJournal of pediatric genetics · 2024Article
- Orthopaedic infections: what have we learned?OTA international : the open access journal of orthopaedic trauma · 2023Review
- The effect of vitamin D supplementation on outcomes following total hip or knee arthroplasty surgery: a rapid systematic review of current evidence.EFORT open reviews · 2022Review
- Vitamin D Receptor Genetic Polymorphisms Associate With a Decreased Susceptibility to Extremity Osteomyelitis Partly by Inhibiting Macrophage Apoptosis Through Inhibition of Excessive ROS ProductionFrontiers in physiology · 2022Article
- How can the orthopedic surgeon ensure optimal vitamin D status in patients operated for an osteoporotic fracture?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Review
- Vitamin D Trajectory after Total Knee Arthroplasty: A Method for Quick Correction in Deficient Patients.Clinics in orthopedic surgery · 2021Article
- The role of Vitamin D in orthopaedic infection: a systematic literature review.Bone & joint open · 2021Article
- The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology-a narrative overview of the literature.Annals of translational medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVitamin D is increasingly being recognized as an important mediator of immune function and may have a preventive role in the pathogenesis of periprosthetic joint infection. To the best of our knowledge, no other study has examined possible associations between periprosthetic joint infection and vitamin D deficiency. We investigated the rate of vitamin D deficiency in patients treated for periprosthetic joint infection and whether vitamin D deficiency is independent of other risk factors for vitamin D deficiency in patients with periprosthetic joint infection.
methodsSerum 25-hydroxyvitamin D (25OHD) levels of every patient scheduled to receive a total prosthesis either of the hip, knee, or shoulder in the orthopaedic department of the Johannes-Guttenberg-University Hospital in Mainz, Germany (109 patients), were measured after admission. Furthermore, serum 25OHD levels were measured for every patient presenting with periprosthetic joint infection (n = 50) or aseptic loosening of the prosthesis (n = 31) scheduled to undergo revision surgery. The prevalence of normal (> 30 ng/ml), insufficient (20-30 ng/ml), and deficient (<20 ng/ml) 25OHD levels was determined.
resultsAll tested patient subgroups showed low vitamin D levels. Statistical analysis found no significant difference in vitamin D levels comparing patients with prosthesis and patients with aseptic prosthesis loosening (p = 0.58). Significant differences in 25OHD levels were found comparing patients with periprosthetic joint infection and patients scheduled for primary arthroplasty (p < 0.001). In addition, we found a significant difference (p < 0,001) in 25OHD levels of patients with periprosthetic joint infection compared with patients with aseptic prosthesis loosening.
conclusionWe found a high frequency of vitamin D deficiency in patients being treated by primary arthroplasty and those with aseptic joint prosthetic loosening and periprosthetic joint infection. Vitamin D deficiency was severe in patients with periprosthetic joint infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.