ReviewClinical reviews in allergy & immunology2015
Crucial Role of Viral Reactivation in the Development of Severe Drug Eruptions: a Comprehensive Review.
Review in Clinical reviews in allergy & immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Cross-reactive tissue-resident memory T lymphocytes-concepts, evidence, and open questions.Journal of translational medicine · 2026Review
- Hidden Drug Rash With Eosinophilia and Systemic Symptoms (DRESS): A Rare Case of Preceding Organ Damage Before Skin Manifestations.Clinical case reports · 2026Article
- Atypical drug-induced hypersensitivity syndrome with multiple organ failure rescued by combined acute blood purification therapy: a case report.International journal of emergency medicine · 2023Article
- HLA-A*24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B*58:01 carriers in a Korean population; a multicenter cross-sectional case-control study.Clinical and translational allergy · 2022Article
- Case report: Severe non-pigmenting fixed drug eruption showing general symptoms caused by chondroitin sulfate sodium.Frontiers in medicine · 2022Article
- Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease.Science translational medicine · 2020Article
- Mechanisms of Severe Cutaneous Adverse Reactions: Recent Advances.Drug safety · 2019Review
- Mild cutaneous reactions to drugs.Acta bio-medica : Atenei Parmensis · 2019Review
- Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions.Annual review of pharmacology and toxicology · 2019Review
- Nevus anemicus: An island of sparing in the setting of drug-induced hypersensitivity.JAAD case reports · 2018Article
- Review
- An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.Journal of immunology research · 2018Review
- Severe Delayed Drug Reactions: Role of Genetics and Viral Infections.Immunology and allergy clinics of North America · 2017Review
- Multiple fixed drug eruption to minocycline at sites of healed burn and zoster: An interesting case of locus minoris resistentiae.JAAD case reports · 2017Article
- Emerging Skin T-Cell Functions in Response to Environmental Insults.The Journal of investigative dermatology · 2017Review
- Gene sharing between Epstein-Barr virus and human immune response genes.Immunologic research · 2017Review
- Allopurinol hypersensitivity: investigating the cause and minimizing the risk.Nature reviews. Rheumatology · 2016Review
- Adverse cutaneous drug eruptions: current understanding.Seminars in immunopathology · 2016Review
- Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back.Clinical and translational allergy · 2015Review
- Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis.Case reports in dermatologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing number of cells, mediators, and pathways have been implicated in severe drug eruptions. Fifteen years ago, we published landmark studies that sparked the current advances in our understanding of the role of viral reactivations in severe drug eruptions. Viral reactivations then became critically important as diagnostic tools, but how precisely they participated in the pathogenesis remained less well-defined. The question of whether viral reactivations are pathogenic or are instead as epiphenomenon of severe tissue damage has plagued the field of drug allergy for some decades. Recent evidence points to a crucial role for tissue-resident memory T (TRM) cells in immune protection against viral infections. Yet immune protection against viral infections is but one side of a coin, the other side of which comprises effector cells capable of mediating severe immunopathology: Once drug antigen is cross-recognized by these T cells, they could be activated to kill surrounding epidermal cells, resulting in drug-induced tissue damage. Such TRM cells could persistently reside in the skin lesions of fixed drug eruptions (FDE) and are most likely a major cell type responsible for the development of FDE. We also discuss the role of regulatory T (Treg) cells in the setting of drug allergy, in which herpesviruses are reactivated in sequence. Although many details of the complicated interactions among viruses, anti-viral immune responses, TRM cells, and Treg cells remain to be elucidated, we review the current status of this rapidly advancing field.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.