ArticleJournal of molecular evolution2014
Conversion of biosynthetic precursors of RNA to those of DNA by photoredox chemistry.
Article in Journal of molecular evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Assembly of catalytic complexes from randomized oligonucleotides.Science advances · 2025Article
- Revisiting the Extinction of the RNA World.Biochemistry · 2022Review
- Illuminating Life's Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules.Journal of the American Chemical Society · 2021Review
- The origin of the central dogma through conflicting multilevel selection.Proceedings. Biological sciences · 2019Article
- Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction.Nature chemistry · 2019Article
- Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice analogues and comparison to meteorites.Nature communications · 2018Article
- Transitioning to DNA genomes in an RNA world.eLife · 2017Article
- A reverse transcriptase ribozyme.eLife · 2017Article
- Spontaneous Assembly of an Organic-Inorganic Nucleic Acid Z-DNA Double-Helix Structure.Angewandte Chemie (International ed. in English) · 2017Article
- The emergence of DNA in the RNA world: an in silico simulation study of genetic takeover.BMC evolutionary biology · 2015Article
- Photobiological Origins of the Field of Genomic Maintenance.Photochemistry and photobiologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Soon after the origin of RNA-based life, depletion of prebiotically synthesised ribonucleotides would have driven the evolution of a biosynthetic pathway to these key building blocks. Ribozyme-catalysed nucleosidation-the key biosynthetic step-requires that ribose and the nucleobases are produced by abiotic chemistry and are relatively stable to the conditions of their synthesis. The most plausible prebiotic synthesis of sugars involves photoreduction of cyanohydrins by hydrogen sulphide in the presence of copper(I) cyanide, and we therefore subjected ribose to these conditions whereupon it was partially converted to 2-deoxyribose. Furthermore, a derivative of uracil is reduced under similar conditions to thymine. Thus, DNA biosynthetic precursors can be formed abiotically from those of RNA allowing for an early evolutionary transition to life based on RNA and DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.