ArticleHeart and vessels2015
Cardiac dysfunction and orthostatic intolerance in patients with myalgic encephalomyelitis and a small left ventricle.
Article in Heart and vessels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Orthostatic intolerance with small heart and/or disequilibrium in patients with myalgic encephalomyelitis/chronic fatigue syndrome: clinical update and paradigm shift.Frontiers in medicine · 2026Review
- Diagnosis of chronic fatigue syndrome using beat-to-beat autonomic measurements.Journal of translational medicine · 2025Article
- Association Between Size of Left Ventricle and Long-Term Cardiovascular Events.Journal of the American Heart Association · 2025Article
- Potential mechanisms underlying pathological fatigue-induced cardiac dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease.Scientific reports · 2025Article
- Orthostatic Intolerance after COVID-19 Infection: Is Disturbed Microcirculation of the Vasa Vasorum of Capacitance Vessels the Primary Defect?Medicina (Kaunas, Lithuania) · 2022Article
- Separating Patients with SEID from Those with CFS in the French ME/CFS Association, with Some Thoughts on Nomenclature.Diagnostics (Basel, Switzerland) · 2022Article
- Paradigm shift to disequilibrium in the genesis of orthostatic intolerance in patients with myalgic encephalomyelitis and chronic fatigue syndrome.International Journal of Cardiology. Hypertension · 2020Article
- Cardiovascular characteristics of chronic fatigue syndrome.Biomedical reports · 2018Article
- The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Frontiers in physiology · 2017Article
- Variability of postural orthostatic tachycardia in patients with myalgic encephalomyelitis and orthostatic intolerance.Heart and vessels · 2016Article
- Mortality in Patients with Myalgic Encephalomyelitis and Chronic Fatigue Syndrome.Fatigue : biomedicine, health & behavior · 2016Article
- Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms.World journal of methodology · 2015Review
- Myalgic Encephalomyelitis: Symptoms and Biomarkers.Current neuropharmacology · 2015Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of chronic fatigue syndrome (CFS) is unknown. Myalgic encephalomyelitis (ME) has been recently postulated to be the cause of CFS. Orthostatic intolerance (OI) has been known as an important symptom in predicting quality of life in CFS patients. Cardiac function may be impaired in patients with ME. The presence or absence of OI was determined both symptomatically and by using a 10-min stand-up test in 40 ME patients. Left ventricular (LV) dimensions and function were determined echocardiographically in the ME patients compared to 40 control subjects. OI was noted in 35 (97%) of the 36 ME patients who could stand up quickly. The mean values for the cardiothoracic ratio, systemic systolic and diastolic pressures, LV end-diastolic diameter (EDD), LV end-systolic diameter, stroke volume index, cardiac index and LV mass index were all significantly smaller in the ME group than in the controls. Both a small LVEDD (<40 mm, 45 vs. 3%) and a low cardiac index (<2 l/ min/mm2, 53 vs. 8%) were significantly more common in the ME group than in the controls. Both heart rate and LV ejection fraction were similar between the groups. In conclusion, a small LV size with a low cardiac output was common in ME patients, in whom OI was extremely common. Cardiac dysfunction with a small heart appears to be related to the symptoms of ME.
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