ArticlePloS one2014
A clinicopathological study of early-stage synchronous bilateral breast cancer: a retrospective evaluation and prospective validation of potential risk factors.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- The relationship between background parenchymal enhancement, amount of fibroglandular tissue and synchronous contralateral breast cancer in preoperative magnetic resonance imaging of newly diagnosed breast cancer patients.BMC medical imaging · 2026Article
- A comparative clinicopathological and survival analysis of synchronous bilateral breast cancers.Histology and histopathology · 2022Article
- Breast Cancer Mortality Trends and Predictions to 2030 and Its Attributable Risk Factors in East and South Asian Countries.Frontiers in nutrition · 2022Article
- Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report.Current oncology (Toronto, Ont.) · 2021Article
- Advanced lesions of synchronous bilateral mammary Paget's disease: a case report.Journal of medical case reports · 2020Article
- SNHG1 Long Noncoding RNA is Potentially Up-Regulated in Colorectal Adenocarcinoma.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors.Asian Pacific journal of cancer prevention : APJCP · 2020Review
- Sclerosing adenosis: Ultrasonographic and mammographic findings and correlation with histopathology.Molecular and clinical oncology · 2017Article
- Oncotype DX in Bilateral Synchronous Primary Invasive Breast Cancer.Annals of surgical oncology · 2016Article
- Estrogen Receptor Expression Is Associated with DNA Repair Capacity in Breast Cancer.PloS one · 2016Article
- Breast Sclerosing Adenosis and Accompanying Malignancies: A Clinicopathological and Imaging Study in a Chinese Population.Medicine · 2015Observational
- Current Status of Breast Reconstruction in Southern China: A 15 Year, Single Institutional Experience of 20,551 Breast Cancer Patients.Medicine · 2015Article
- Sclerosing adenosis as a predictor of breast cancer bilaterality and multicentricity.Virchows Archiv : an international journal of pathology · 2015Article
- Article
- Synchronous bilateral breast cancer patients submitted to conservative treatment and brachytherapy - The experience of a service.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyReview
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9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to investigate potential risk factors for synchronous bilateral breast cancer sBBC).
methodsA retrospective analysis was performed of patients diagnosed and treated with operable bilateral breast cancer (BBC) between June 2007 and December 2011. Risk factors for sBBC were evaluated in this cohort and further validated in a prospective observational validation analysis of patients between January 2012 and December 2012. Patients treated with operable unilateral breast cancer during the same period were used as a control group.
resultsA total of 11,247 patients with primary breast cancer underwent operations at the Fudan University Shanghai Cancer Center between June 2007 and December 2012. The incidence of sBBC was 1.6%. The age at diagnosis (HR = 2.4, 95% C.I.: 1.4-4.0, p = 0.001), presence of sclerosing adenosis (HR = 11.8, 95% C.I.: 5.3-26.3, p<0.001), lobular carcinoma component involvement (HR = 5.6, 95% C.I.: 2.6-12.1, p<0.001), and family history of first-degree relatives with breast cancer (HR = 2.0, 95% C.I.: 1.1-3.4, p<0.001) were independent risk factors for sBBC. A subsequent validation study failed to confirm the significance of family history. No significant difference on survival was found between patients with early-stage sBBC and control cases.
conclusionsPatients with the presence of sclerosing in the affected breast, and lobular carcinoma component involvement may be at high risk for developing sBBC. This study supports the hypothesis that the host-carcinoma biological relationship, especially for the tumor microenvironment, played a critical role in the carcinogenesis of sBBC.
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