ArticlePloS one2014
Homocysteine and carotid plaque stability: a cross-sectional study in Chinese adults.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Risk factors for small vessel disease in adults with atherosclerosis: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Correlation of composite inflammatory indices and homocysteine with the severity of acute ischemic stroke: A retrospective study.Medicine · 2026Article
- Analysis of risk factors for carotid artery plaque in asymptomatic adults.BMC cardiovascular disorders · 2024Article
- Additive effect between homocysteine and low-density-lipoprotein cholesterol upon incidence of novel carotid plaque formation: data from a Chinese community-based cohort.BMC cardiovascular disorders · 2023Article
- Association of homocysteine with carotid atherosclerosis in hypertension.Journal of human hypertension · 2023Article
- Characteristics of the gut microbiota of patients with symptomatic carotid atherosclerotic plaques positive for bacterial genetic material.Frontiers in cellular and infection microbiology · 2023Article
- Association between cumulative exposure to different lipid parameters and risk of newly developed carotid plaque.Stroke and vascular neurology · 2021Article
- Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9.Lipids in health and disease · 2020Article
- Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review.Annals of translational medicine · 2019Article
- Plasma homocysteine levels and intracranial plaque characteristics: association and clinical relevance in ischemic stroke.BMC neurology · 2018Article
- Changes in total homocysteine levels after acute stroke and recurrence of stroke.Scientific reports · 2018Article
- Methylenetetrahydrofolate reductase gene A1298C polymorphism and gene-environment interactions are associated with carotid plaque in a south Chinese population.International journal of clinical and experimental pathology · 2017Article
- Sex Differences in Prevalence of and Risk Factors for Carotid Plaque among Adults: A Population-based Cross-Sectional Study in Rural China.Scientific reports · 2016Article
- Homocysteine and Its Relationship to Asymptomatic Carotid Stenosis in a Chinese Community Population.Scientific reports · 2016Article
- The Association between Serum Uric Acid Levels and the Prevalence of Vulnerable Atherosclerotic Carotid Plaque: A Cross-sectional Study.Scientific reports · 2015Observational
- Carotid Plaque Stiffness Measured with Supersonic Shear Imaging and Its Correlation with Serum Homocysteine Level in Ischemic Stroke Patients.Korean journal of radiologyArticle
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThis study aimed to explore the possible association of plasma total homocysteine with carotid plaque stability.
methodsA cross-sectional study was conducted from 2010 to 2011. A stratified random sample of 2,919 Chinese participants aged 40 years or older was enrolled. Plasma total homocysteine levels were measured and carotid plaques were evaluated by ultrasonography. Logistic regression model was used to analyze the association of homocysteine levels to the progression of carotid plaque development, while adjusting for demographics and vascular risk factors.
resultsThe mean level of plasma homocysteine in the subjects was 14.9 µmol/l. Along with increase in homocysteine level, the risk of advanced carotid plaque elevated (odds ratio = 1.28; 95% confidence interval = 1.09-1.51) after adjusting for age, sex, and other potential confounders. Stratified by sex, higher homocysteine level was strongly associated with advanced carotid plaque in men (OR = 1.41; 95% confidence interval = 1.17-1.70), but not in women.
conclusionThe findings suggest that plasma level of homocysteine may be associated with advanced carotid plaque, which constitutes high risks of stroke, in male Chinese adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.