ArticleNature communications2014
Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 90 citations in OpenAlex.
- FvGI-FvCO-FvFT1 pathway activates FvTFL1 in long days to repress flowering in woodland strawberry (Fragaria vesca).The New phytologist · 2026Article
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- Constitution and function of intergenic genome regions in cultivated versus annual wild soybean in China.Journal of integrative plant biology · 2026Article
- Detection and validation of QTLs for flowering time in morning glory.Breeding science · 2025Article
- Multiplexed profiling of transcriptional regulators in plant cells.Nature biotechnology · 2025Article
- Article
- More than flowering: CONSTANS plays multifaceted roles in plant development and stress responses.Journal of integrative plant biology · 2025Review
- Genome-wide analysis of AP2/ERF transcription Factors inFrontiers in plant science · 2025Article
- Potato: from functional genomics to genetic improvement.Molecular horticulture · 2024Review
- Clinal Variation in Short Tandem Repeats Linked to Gene Expression in Sunflower (Biomolecules · 2024Article
- Circadian and photoperiodic regulation of the vegetative to reproductive transition in plants.Communications biology · 2024Review
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- Comparative Proteomic and Metabonomic Profiling of Buds with Different Flowering Capabilities Reveal Novel Regulatory Mechanisms of Flowering in Apple.Plants (Basel, Switzerland) · 2023Article
- Evolutionary Consequences of Functional and Regulatory Divergence of HD-Zip I Transcription Factors as a Source of Diversity in Protein Interaction Networks in Plants.Journal of molecular evolution · 2023Review
- Exploring plant cis-regulatory elements at single-cell resolution: overcoming biological and computational challenges to advance plant research.The Plant journal : for cell and molecular biology · 2023Review
- From Floral Induction to Blooming: The Molecular Mysteries of Flowering in Woody Plants.International journal of molecular sciences · 2022Review
- The genetic basis of natural variation in the timing of vegetative phase change in Arabidopsis thaliana.Development (Cambridge, England) · 2022Article
- Article
- Functional homoeologous alleles of CONSTANS contribute to seasonal crop type in rapeseed.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Evolution of pathogen response genes associated with increased disease susceptibility during adaptation to an extreme drought in a Brassica rapa plant population.BMC ecology and evolution · 2021Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The onset of flowering, the change from vegetative to reproductive development, is a major life history transition in flowering plants. Recent work suggests that mutations in cis-regulatory mutations should play critical roles in the evolution of this (as well as other) important adaptive traits, but thus far there has been little evidence that directly links regulatory mutations to evolutionary change at the species level. While several genes have previously been shown to affect natural variation in flowering time in Arabidopsis thaliana, most either show protein-coding changes and/or are found at low frequency (<5%). Here we identify and characterize natural variation in the cis-regulatory sequence in the transcription factor CONSTANS that underlies flowering time diversity in Arabidopsis. Mutation in this regulatory motif evolved recently and has spread to high frequency in Arabidopsis natural accessions, suggesting a role for these cis-regulatory changes in adaptive variation of flowering time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.