ArticleScientific reports2014
Increasing mechanical strength of gelatin hydrogels by divalent metal ion removal.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed, 467 citations in OpenAlex.
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- Structuring the Future of Cultured Meat: Hybrid Gel-Based Scaffolds for Edibility and Functionality.Gels (Basel, Switzerland) · 2025Review
- One-Pot Synthesis of Gelatin/Gum Arabic Hydrogels Embedding Silver Nanoparticles as Antibacterial Materials.Gels (Basel, Switzerland) · 2025Article
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- Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies.Exploration (Beijing, China) · 2025Review
- Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery.Archives of pharmacal research · 2025Review
- Scaffold Biomaterials in the Development of Cultured Meat: A Review.Food science of animal resources · 2025Review
- Hydrogel-Based Bioinks for Coaxial and Triaxial Bioprinting: A Review of Material Properties, Printing Techniques, and Applications.Polymers · 2025Review
- Accelerated dermal wound healing in diabetic mice by a HJournal of materials chemistry. B · 2025Article
- Three-Dimensional Printing of Hydrogel as Skin Substitute and Comparative Evaluation of Melanin Production.Bioengineering (Basel, Switzerland) · 2025Article
- Nanoengineered Shape-Memory Hemostat.Small science · 2025Article
- Effects of Hydroxyapatite Additions on Alginate Gelation Kinetics During Cross-Linking.Polymers · 2025Article
- Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization.Gels (Basel, Switzerland) · 2025Article
- Hydrogels for preventing post-endoscopic submucosal dissection stenosis in early esophageal cancer: a comprehensive literature review.Therapeutic advances in gastroenterology · 2025Review
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The usage of gelatin hydrogel is limited due to its instability and poor mechanical properties, especially under physiological conditions. Divalent metal ions present in gelatin such as Ca(2+) and Fe(2+) play important roles in the gelatin molecule interactions. The objective of this study was to determine the impact of divalent ion removal on the stability and mechanical properties of gelatin gels with and without chemical crosslinking. The gelatin solution was purified by Chelex resin to replace divalent metal ions with sodium ions. The gel was then chemically crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). Results showed that the removal of divalent metal ions significantly impacted the formation of the gelatin network. The purified gelatin hydrogels had less interactions between gelatin molecules and form larger-pore network which enabled EDC to penetrate and crosslink the gel more efficiently. The crosslinked purified gels showed small swelling ratio, higher crosslinking density and dramatically increased storage and loss moduli. The removal of divalent ions is a simple yet effective method that can significantly improve the stability and strength of gelatin hydrogels. The in vitro cell culture demonstrated that the purified gelatin maintained its ability to support cell attachment and spreading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.