ArticleScientific reports2014
Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- CD9 protects the sperm from cytotoxic factors in the epididymis as extracellular components.microPublication biology · 2023Article
- MicroRNAs secreted by human preimplantation embryos and IVF outcome.Reproductive biology and endocrinology : RB&E · 2022Article
- Article
- A Comparative Study of Gene Expression in Menstrual Blood-Derived Stromal Cells between Endometriosis and Healthy Women.BioMed research international · 2022Article
- Regenerative Potential of Menstrual Blood-Derived Stem Cells and Platelet-Derived Growth Factor in Endometrial Injury.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Serial gene co-expression network approach to mine biological meanings from integrated transcriptomes of the porcine endometrium during estrous cycle.Functional & integrative genomics · 2020Article
- Alterations of IL-1 and VEGF After Ischemia-Reperfusion Injured Uterus and Ovary in Rats.Medeniyet medical journal · 2020Article
- Microexosomes versus exosomes: Shared components but distinct structures.Regenerative therapy · 2019Article
- Membrane protein CD9 is repositioned and released to enhance uterine function.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Comparison of CD9 & CD146 markers in endometrial stromal cells of fertile & infertile females.The Indian journal of medical research · 2018Article
- Exosomes versus microexosomes: Shared components but distinct functions.Journal of plant research · 2017Review
- Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model.Stem cells translational medicine · 2016Article
- Hypoxia regulates CD9-mediated keratinocyte migration via the P38/MAPK pathway.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, uterine epithelium is remodeled cyclically throughout adult life for pregnancy. Despite the expression of CD9 in the uterine epithelium, its role in maternal reproduction is unclear. Here, we addressed this issue by examining uterine secretions collected from patients undergoing fertility treatment and fertilization-competent Cd9(-/-) mice expressing CD9-GFP in their eggs (Cd9(-/-)TG). CD9 in uterine secretions was observed as extracellular matrix-like feature, and its amount of the secretions associated with repeated pregnancy failures. We also found that the litter size of Cd9(-/-)TG female mice was significantly reduced after their first birth. Severely delayed re-epithelialization of the endometrium was then occurred. Concomitantly, vascular endothelial growth factor (VEGF) was remarkably reduced in the uterine secretions of Cd9(-/-)TG female mice. These results provide the first evidence that CD9-mediated VEGF secretion plays a role in re-epithelialization of the uterus.
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