ArticlePloS one2014
Infection of apple by apple stem grooving virus leads to extensive alterations in gene expression patterns but no disease symptoms.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Transcriptomic responses to biotic stresses in Malus x domestica: a meta-analysis study.Scientific reports · 2018Pooled it
- Long-term Impact of Virus-Free Apple Seedlings on Fruit Quality and Yield in Commercial Orchards of Korea.The plant pathology journal · 2025Article
- Managing Plant Viruses in Tissue-Cultured Apple and Grapevine: Strategies for Detection and Eradication.The plant pathology journal · 2025Review
- Transmission of apple stem grooving virus (Capillovirus mali) to apple from the soil-borne fungus Fusarium solani.BMC plant biology · 2025Article
- Comprehensive Virome Profiling of Apple Mosaic Disease-Affected Trees in Iran Using RT-PCR and Next-Generation Sequencing.Viruses · 2025Article
- Article
- Evolution and biogeography of apple stem grooving virus.Virology journal · 2023Article
- Field detection of multiple RNA viruses/viroids in apple using a CRISPR/Cas12a-based visual assay.Plant biotechnology journal · 2021Article
- Article
- AppleMDO: A Multi-Dimensional Omics Database for Apple Co-Expression Networks and Chromatin States.Frontiers in plant science · 2019Article
- Global Transcriptomic Changes Induced by Infection of Cucumber (Frontiers in microbiology · 2017Article
- Gaining Insight into Exclusive and Common Transcriptomic Features Linked with Biotic Stress Responses in Malus.Frontiers in plant science · 2017Article
- Simultaneous detection of three pome fruit tree viruses by one-step multiplex quantitative RT-PCR.PloS one · 2017Article
- Characterization of virus-derived small interfering RNAs in Apple stem grooving virus-infected in vitro-cultured Pyrus pyrifolia shoot tips in response to high temperature treatment.Virology journal · 2016Article
- Integrated analyses using RNA-Seq data reveal viral genomes, single nucleotide variations, the phylogenetic relationship, and recombination for Apple stem grooving virus.BMC genomics · 2016Article
- Omics studies of citrus, grape and rosaceae fruit trees.Breeding science · 2016Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the molecular basis of viral diseases, transcriptome profiling has been widely used to correlate host gene expression change patterns with disease symptoms during viral infection in many plant hosts. We used infection of apple by Apple stem grooving virus (ASGV), which produces no disease symptoms, to assess the significance of host gene expression changes in disease development. We specifically asked the question of whether such asymptomatic infection is attributed to limited changes in host gene expression. Using RNA-seq, we identified a total of 184 up-regulated and 136 down-regulated genes in apple shoot cultures permanently infected by ASGV in comparison with virus-free shoot cultures. As in most plant hosts showing disease symptoms during viral infection, these differentially expressed genes encode known or putative proteins involved in cell cycle, cell wall biogenesis, response to biotic and abiotic stress, development and fruit ripening, phytohormone function, metabolism, signal transduction, transcription regulation, translation, transport, and photosynthesis. Thus, global host gene expression changes do not necessarily lead to virus disease symptoms. Our data suggest that the general approaches to correlate host gene expression changes under viral infection conditions to specific disease symptom, based on the interpretation of transcription profiling data and altered individual gene functions, may have limitations depending on particular experimental systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.