ArticleNeuroImage2014
Resting state functional connectivity of the basal nucleus of Meynert in humans: in comparison to the ventral striatum and the effects of age.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Functional Subdivisions of Magnocellular Cell Groups in Human Basal Forebrain: Test-Retest Resting-State Study at Ultra-high Field, and Meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2019Pooled it
- Human Pregenual Anterior Cingulate Cortex: Structural, Functional, and Connectional Heterogeneity.Cerebral cortex (New York, N.Y. : 1991) · 2019Pooled it
- Trial
- Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei: a pharmacological fMRI study.The Journal of investigative dermatology · 2015Trial
- Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults.Journal of psychiatric research · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Hypothalamic connectivities and self-evaluated aggression in young adults.bioRxiv : the preprint server for biology · 2024Article
- Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression.PLoS computational biology · 2024Article
- Sleep Deficits Inter-Link Lower Basal Forebrain-Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men.The international journal of neuropsychopharmacology · 2023Article
- Basal forebrain functional connectivity as a mediator of associations between cardiorespiratory fitness and cognition in healthy older women.Brain imaging and behavior · 2023Article
- Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals.The international journal of neuropsychopharmacology · 2023Article
- Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Cholinergic relevant functional reactivity is associated with dopamine responsiveness of tremor in Parkinson's disease.Brain imaging and behavior · 2022Article
- Anticholinergic drugs and forebrain magnetic resonance imaging changes in cognitively normal people and those with mild cognitive impairment.European journal of neurology · 2022Article
- Relationship between plasma clozapine/N-desmethylclozapine and changes in basal forebrain-dorsolateral prefrontal cortex coupling in treatment-resistant schizophrenia.Schizophrenia research · 2022Article
- Distinct alterations of functional connectivity of the basal forebrain subregions in insomnia disorder.Frontiers in psychiatry · 2022Article
- Rhythmicity in heart rate and its surges usher a special period of sleep, a likely home for PGO waves.Current research in physiology · 2022Article
- The functional connectivity and neuropsychology underlying mental planning operations: data from the digital clock drawing test.Frontiers in aging neuroscience · 2022Article
- The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use.The international journal of neuropsychopharmacology · 2021Article
- Altered Functional Connectivity of the Basal Nucleus of Meynert in Subjective Cognitive Impairment, Early Mild Cognitive Impairment, and Late Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The basal nucleus of Meynert (BNM) provides the primary cholinergic inputs to the cerebral cortex. Loss of neurons in the BNM is linked to cognitive deficits in Alzheimer's disease and other degenerative conditions. Numerous animal studies described cholinergic and non-cholinergic neuronal responses in the BNM; however, work in humans has been hampered by the difficulty of defining the BNM anatomically. Here, on the basis of a previous study that delineated the BNM of post-mortem human brains in a standard stereotaxic space, we sought to examine functional connectivity of the BNM, as compared to the nucleus accumbens (or ventral striatum, VS), in a large resting state functional magnetic resonance imaging data set. The BNM and VS shared but also showed a distinct pattern of cortical and subcortical connectivity. Compared to the VS, the BNM showed stronger positive connectivity with the putamen, pallidum, thalamus, amygdala and midbrain, as well as the anterior cingulate cortex, supplementary motor area and pre-supplementary motor area, a network of brain regions that respond to salient stimuli and orchestrate motor behavior. In contrast, compared to the BNM, the VS showed stronger positive connectivity with the ventral caudate and medial orbitofrontal cortex, areas implicated in reward processing and motivated behavior. Furthermore, the BNM and VS each showed extensive negative connectivity with visual and lateral prefrontal cortices. Together, the distinct cerebral functional connectivities support the role of the BNM in arousal, saliency responses and cognitive motor control and the VS in reward related behavior. Considering the importance of BNM in age-related cognitive decline, we explored the effects of age on BNM and VS connectivities. BNM connectivity to the visual and somatomotor cortices decreases while connectivity to subcortical structures including the midbrain, thalamus, and pallidum increases with age. These findings of age-related changes of cerebral functional connectivity of the BNM may facilitate research of the neural bases of cognitive decline in health and illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.