Evidence map›Paper›PMID 24735921›Full record

ArticleCancer cell2014

Harnessing the hidden antitumor power of the MLL-AF4 oncogene to fight leukemia.

Smita Matkar, Bryson W Katona, Xianxin Hua

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Smita MatkarAbramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Bryson W KatonaAbramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Xianxin HuaAbramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA. Electronic address: huax@mail.med.upenn.edu.
Cancer Research Institute · US

Funding

Beta Cell Regeneration by an Epigenetic PathwayR01DK097555 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HUA, XIANXIN · 2013 to 2016
$1.4M
Link of Beta Cell Proliferation and Type 2 Diabetes to Epigenetic RegulationR01DK085121 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HUA, XIANXIN · 2010 to 2013
$1.4M
NIDDK NIH HHS R01 DK085121NIDDK NIH HHS R01-DK085121NIDDK NIH HHS R01 DK097555
6 · The paper itself

Abstract

It is unclear whether the antiproliferative/proapoptotic activity of oncogenes can be pharmacologically reactivated in cancer cells. In this issue of Cancer Cell, Liu and colleagues report that a proteasome inhibitor reactivates an MLL-AF4 controlled antitumor program to kill leukemia cells in an oncogene dose- and cell type-dependent manner.

Indexed as

AnimalsHistone-Lysine N-MethyltransferaseHumansMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaProteasome InhibitorsHistone-Lysine N-MethyltransferaseKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionProteasome Inhibitors

Identifiers

PMID24735921
PMCPMC4711792
OpenAlexW1971747404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.