Evidence map›Paper›PMID 24735781›Full record

ArticleClinical and translational allergy2014

Allergic sensitization: food- and protein-related factors.

Scott McClain, Christal Bowman, Montserrat Fernández-Rivas, Gregory S Ladics, Ronald van Ree

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational allergy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Frontiers in nutrition · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. The Initiation of Th2 Immunity Towards Food Allergens.International journal of molecular sciences · 2018
    Review
  10. Article
  11. Prevalence and clinical features of adverse food reactions in Portuguese adults.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016
    Article
  12. Sensitizing properties of proteins: executive summary.Clinical and translational allergy · 2014
    Article
  13. Allergic sensitization: screening methods.Clinical and translational allergy · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Scott McClainSyngenta Crop Protection, LLC, 3054 E, Cornwallis Road, Research Triangle Park, NC, USA. scott.mcclain@syngenta.com.
Christal Bowman
Montserrat Fernández-Rivas
Gregory S Ladics
Ronald van Ree
Bayer (Germany) · DEDuPont (United States) · USHospital Clínico San Carlos · ESSyngenta (Switzerland) · CHUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Presented here are emerging capabilities to precisely measure endogenous allergens in soybean and maize, consideration of food matrices on allergens, and proteolytic activity of allergens. Also examined are observations of global allergy surveys and the prevalence of food allergy across different locales. Allergenic potential is considered in the context of how allergens can be characterized for their biochemical features and the potential for proteins to initiate a specific immune response. Some of the limitations in performing allergen characterization studies are examined. A combination of physical traits of proteins, the molecular interaction between cells and proteins in the human body, and the uniqueness of human culture play a role in understanding and eventually predicting protein allergy potential. The impact of measuring food allergens on determining safety for novel food crops and existing allergenic foods was highlighted with the conclusion that measuring content without the context of clinically relevant thresholds adds little value to safety. These data and findings were presented at a 2012 international symposium in Prague organized by the Protein Allergenicity Technical Committee of the International Life Sciences Institute's Health and Environmental Sciences Institute.

Identifiers

PMID24735781
PMCPMC3989781
OpenAlexW2130201295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.