ArticleJournal of neurotrauma2015
Group-wise evaluation and comparison of white matter fiber strain and maximum principal strain in sports-related concussion.
Article in Journal of neurotrauma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
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Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Uncovering the hidden effects of repetitive subconcussive head impact exposure: A mega-analytic approach characterizing seasonal brain microstructural changes in contact and collision sports athletes.Human brain mapping · 2024Pooled it
- Head-Impact-Measurement Devices: A Systematic Review.Journal of athletic training · 2017Pooled it
- Estimated Brain Tissue Response Following Impacts Associated With and Without Diagnosed Concussion.Annals of biomedical engineering · 2018Trial
- In Vivo Brain Deformation in a Sheep Model of Rapid Head Rotation.Annals of biomedical engineering · 2026Article
- A model of axonal damage accumulation from real-world head impact exposure.Annals of biomedical engineering · 2026Article
- Article
- Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026Article
- An Evaluation of Tentorium and Brainstem Influences on Intracranial Displacements and Strains.Annals of biomedical engineering · 2025Article
- Surface-based versus voxel-based finite element head models: comparative analyses of strain responses.Biomechanics and modeling in mechanobiology · 2025Article
- A fast-modeling framework for personalized human body models based on a single image.Medical & biological engineering & computing · 2025Article
- Immediate and Transient Perturbances in EEG Within Seconds Following Controlled Soccer Head Impact.Annals of biomedical engineering · 2024Article
- On-field Head Acceleration Exposure Measurements Using Instrumented Mouthguards: Multi-stage Screening to Optimize Data Quality.Annals of biomedical engineering · 2024Article
- The Impact of Drop Test Conditions on Brain Strain Location and Severity: A Novel Approach Using a Deep Learning Model.Annals of biomedical engineering · 2024Article
- Subject-specific finite element head models for skull fracture evaluation-a new tool in forensic pathology.International journal of legal medicine · 2024Article
- Neuroimaging, wearable sensors, and blood-based biomarkers reveal hyperacute changes in the brain after sub-concussive impacts.Brain multiphysics · 2023Article
- Longitudinal Associations of Clinical and Biochemical Head Injury Biomarkers With Head Impact Exposure in Adolescent Football Players.JAMA network open · 2023Article
- Biomechanics of Traumatic Head and Neck Injuries on Women: A State-of-the-Art Review and Future Directions.Biology · 2023Review
- Physics-Informed Machine Learning Improves Detection of Head Impacts.Annals of biomedical engineering · 2022Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- American Football Helmet Effectiveness Against a Strain-Based Concussion Mechanism.Annals of biomedical engineering · 2022Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
Sports-related concussion is a major public health problem in the United States and yet its biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation as a potential injury mechanism; however, current response-based injury predictors (e.g., maximum principal strain, ε(ep)) typically do not incorporate axonal orientations. We investigated the significance of white matter (WM) fiber orientation in strain estimation and compared fiber strain (ε(n)) with ε(ep) for 11 athletes with a clinical diagnosis of concussion. Geometrically accurate subject-specific head models with high mesh quality were created based on the Dartmouth Head Injury Model (DHIM), which was successfully validated (performance categorized as "good" to "excellent"). For WM regions estimated to be exposed to high strains using a range of injury thresholds (0.09-0.28), substantial differences existed between ε(n) and ε(ep) in both distribution (Dice coefficient of 0.13-0.33) and extent (∼ 5-10-fold differences), especially at higher threshold levels and higher rotational acceleration magnitudes. For example, an average of 3.2% vs. 29.8% of WM was predicted above an optimal threshold of 0.18 established from an in vivo animal study using ε(n) and ε(ep), respectively, with an average Dice coefficient of 0.14. The distribution of WM regions with high ε(n) was consistent with typical heterogeneous patterns of WM disruptions in diffuse axonal injury, and the group-wise extent at the optimal threshold matched well with the percentage of WM voxels experiencing significant longitudinal changes of fractional anisotropy and mean diffusivity (3.2% and 3.44%, respectively) found from a separate independent study. These results suggest the significance of incorporating WM microstructural anisotropy in future brain injury studies.
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Registered trials
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