Trial reportClinical endocrinology2014
Subcutaneous pulsatile glucocorticoid replacement therapy.
Trial report in Clinical endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Corticosteroids in septic shock: a systematic review and network meta-analysis.Critical care (London, England) · 2017Pooled it
- Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2016Guideline
- Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial.Journal of internal medicine · 2024Trial
- Trial
- A phase 2 study of Chronocort, a modified-release formulation of hydrocortisone, in the treatment of adults with classic congenital adrenal hyperplasia.The Journal of clinical endocrinology and metabolism · 2015Trial
- Dual-release hydrocortisone improves body composition and the glucometabolic profile in patients with secondary adrenal insufficiency.Endocrine · 2024Article
- Recent Advances in Multiplexed Wearable Sensor Platforms for Real-Time Monitoring Lifetime Stress: A Review.Biosensors · 2023Review
- Applications of cosinor rhythmometry in pharmacology.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency.Pharmaceutics · 2021Article
- Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis.Endocrine · 2021Review
- Dynamics of ACTH and Cortisol Secretion and Implications for Disease.Endocrine reviews · 2020Review
- Dynamic Pituitary-Adrenal Interactions in the Critically Ill after Cardiac Surgery.The Journal of clinical endocrinology and metabolism · 2020Article
- Mathematical Modelling of Endocrine Systems.Trends in endocrinology and metabolism: TEM · 2019Review
- The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids.Endocrine reviews · 2017Review
- Novel treatment strategies in congenital adrenal hyperplasia.Current opinion in endocrinology, diabetes, and obesity · 2016Review
- Using Cox cluster processes to model latent pulse location patterns in hormone concentration data.Biostatistics (Oxford, England) · 2016Article
- Plasma, salivary and urinary cortisol levels following physiological and stress doses of hydrocortisone in normal volunteers.BMC endocrine disorders · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The glucocorticoid hormone cortisol is released in pulses resulting in a complex and dynamic ultradian rhythm of plasma cortisol that underlies the classical circadian rhythm. These oscillating levels are also seen at the level of tissues such as the brain and trigger pulses of gene activation and downstream signalling. Different patterns of glucocorticoid presentation (constant vs pulsatile) result not only in different patterns of gene regulation but also in different neuroendocrine and behavioural responses. Current 'optimal' glucocorticoid replacement therapy results in smooth hormone blood levels and does not replicate physiological pulsatile cortisol secretion. Validation of a novel portable pulsatile continuous subcutaneous delivery system in healthy volunteers under dexamethasone and metyrapone suppression. Pulsatile subcutaneous hydrocortisone more closely replicates physiological circadian and ultradian rhythmicity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.