ArticleBMC infectious diseases2014
Respiratory viral pathogens among Singapore military servicemen 2009-2012: epidemiology and clinical characteristics.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Etiology of febrile respiratory infections in the general adult population in Singapore, 2007-2013.Heliyon · 2021Article
- Human Metapneumovirus: Etiological Agent of Severe Acute Respiratory Infections in Hospitalized and Deceased Patients with a Negative Diagnosis of Influenza.Pathogens (Basel, Switzerland) · 2020Article
- Evidence for Cross-Protection Against Subsequent Febrile Respiratory Illness Episodes From Prior Infections by Different Viruses Among Singapore Military Recruits 2009-2014.The Journal of infectious diseases · 2019Article
- The molecular epidemiology of respiratory viruses in military trainees in Iran.Medical journal of the Islamic Republic of Iran · 2019Article
- Literature review of the epidemiology of influenza B disease in 15 countries in the Asia-Pacific region.Influenza and other respiratory viruses · 2018Review
- Epidemiologic analysis of respiratory viral infections among Singapore military servicemen in 2016.BMC infectious diseases · 2018Article
- Comparison between Saliva and Nasopharyngeal Swab Specimens for Detection of Respiratory Viruses by Multiplex Reverse Transcription-PCR.Journal of clinical microbiology · 2017Article
- A Report of Adult Human Adenovirus Infections in a Tertiary Hospital.Open forum infectious diseases · 2017Article
- Risk factors for febrile respiratory illness and mono-viral infections in a semi-closed military environment: a case-control study.BMC infectious diseases · 2015Article
- Respiratory Infections in the U.S. Military: Recent Experience and Control.Clinical microbiology reviews · 2015Review
- Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia.Emerging infectious diseases · 2015Article
- Clinical differences between respiratory viral and bacterial mono- and dual pathogen detected among Singapore military servicemen with febrile respiratory illness.Influenza and other respiratory viruses · 2015Article
- Rhinitis in the first 18 months of life: exploring the role of respiratory viruses.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2015Article
- Emerging and re-emerging infectious diseases: challenges and opportunities for militaries.Military Medical Research · 2014Article
- Frequency of viral etiology in symptomatic adult upper respiratory tract infections.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have comprehensively described tropical respiratory disease surveillance in military populations. There is also a lack of studies comparing clinical characteristics of the non-influenza pathogens with influenza and amongst themselves.
methodsFrom May 2009 through October 2012, 7733 consenting cases of febrile respiratory illness (FRI) (temperature [greater than or equal to]37.5 degrees C with cough or sorethroat) and controls in the Singapore military had clinical data and nasal washes collected prospectively. Nasal washes underwent multiplex PCR, and the analysis was limited to viral mono-infections.
results49% of cases tested positive for at least one virus, of whom 10% had multiple infections. 53% of the FRI cases fulfilled the definition of influenza-like illness (ILI), of whom 52% were positive for at least one virus. The most frequent etiologies for mono-infections among FRI cases were Influenza A(H1N1)pdm09 (13%), Influenza B (13%) and coxsackevirus (9%). The sensitivity, specificity, positive predictive value and negative predictive value of ILI for influenza among FRI cases were 72%, 48%, 40% and 69% respectively. On logistic regression, there were marked differences in the prevalence of different symptoms and signs between viruses with fever more prevalent amongst influenza and adenovirus infections than other viruses.
conclusionThere are multiple viral etiologies for FRI and ILI with differing clinical symptoms in the Singapore military. Influenza and coxsackevirus were the most common etiology for FRI, while influenza and adenoviruses displayed the most febrile symptoms. Further studies should explore these differences and possible interventions.
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