ArticleProceedings of the National Academy of Sciences of the United States of America1989
Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 165 citations in OpenAlex.
- L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor.Clinical & experimental metastasis · 2013Article
- A novel role for vitamin K1 in a tyrosine phosphorylation cascade during chick embryogenesis.The Journal of clinical investigation · 1997Article
- A Drosophila receptor-type tyrosine kinase (DFR1) acts as a fibroblast growth factor receptor in Xenopus embryos.Development, growth & differentiation · 1996Article
- Intracellular signaling is changed after clustering of the neural cell adhesion molecules axonin-1 and NgCAM during neurite fasciculation.The Journal of cell biology · 1996Article
- Fibroblast growth factor 2 can replace ectodermal signaling for feather development.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Identification of soluble forms of the fibroblast growth factor receptor in blood.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Biochemical characterization of the molecular interaction between recombinant basic fibroblast growth factor and a recombinant soluble fibroblast growth factor receptor.The Biochemical journal · 1993Article
- Identification of a cysteine-rich receptor for fibroblast growth factors.Molecular and cellular biology · 1992Article
- Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.The Journal of cell biology · 1992Article
- Elimination of smooth muscle cells in experimental restenosis: targeting of fibroblast growth factor receptors.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.The EMBO journal · 1992Article
- The beta-PDGF receptor induces neuronal differentiation of PC12 cells.Molecular biology of the cell · 1992Article
- K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.Japanese journal of cancer research : Gann · 1991Article
- Paxillin is a major phosphotyrosine-containing protein during embryonic development.The Journal of cell biology · 1991Article
- Ligand-induced transphosphorylation between different FGF receptors.The EMBO journal · 1991Article
- A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.Molecular and cellular biology · 1991Article
- The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.Molecular and cellular biology · 1991Article
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2 authors at 1 institution in 1 country.
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Abstract
To identify the protein-tyrosine kinases that are expressed during chicken embryonic development, a 10-day chicken embryo cDNA expression library was screened with anti-phosphotyrosine antibodies. Of the positive clones isolated, many encoded the same protein-tyrosine kinase, which we designate Cek1 (chicken embryo kinase 1). Its amino acid sequence suggests that the Cek1 protein is a transmembrane tyrosine kinase and presumably the receptor for an unknown ligand. Antibodies prepared to the cloned Cek1 kinase recognize, in immunoblotting experiments, two protein bands with apparent molecular weights of 100,000 and 110,000. The Cek1 protein was detected in many chicken embryonic tissues, but not in the corresponding adult tissues (with the exception of brain). The Cek1 kinase appears to be very closely related to two protein-tyrosine kinases whose partial sequences have been recently determined, human Flg and mouse Bek. Cloning using anti-phosphotyrosine antibodies has allowed us to detect, in addition to Cek1, several other protein-tyrosine kinases that are expressed during chicken embryonic development, some of which have not been previously identified.
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