ArticleJournal of biomedical nanotechnology2014
In vivo imaging of infection using a bacteria-targeting optical nanoprobe.
Article in Journal of biomedical nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Panoramic description of ROS-based nanotechnology for osteomyelitis therapy: Challenges, opportunities, and prospects.Theranostics · 2026Review
- Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic-Antimicrobial Peptide Conjugates.Antibiotics (Basel, Switzerland) · 2024Review
- Bacteria eat nanoprobes for aggregation-enhanced imaging and killing diverse microorganisms.Nature communications · 2022Article
- Effect of the Kanghuier Transparent Hydrocolloid Dressing in Preventing Central Venous Catheter Infection and Phlebitis after Cardiac Surgery.Computational and mathematical methods in medicine · 2022Article
- Recent Progress in the Molecular Imaging of Tumor-Treating Bacteria.Nuclear medicine and molecular imaging · 2021Review
- Imaging Inflammation - From Whole Body Imaging to Cellular Resolution.Frontiers in immunology · 2021Review
- Optical Identification of Middle Ear Infection.Molecules (Basel, Switzerland) · 2020Review
- Imaging in Chronic Wound Diagnostics.Advances in wound care · 2020Review
- Maltotriose-based probes for fluorescence and photoacoustic imaging of bacterial infections.Nature communications · 2020Article
- Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment.Acta biomaterialia · 2019Article
- Development of a dual-wavelength fluorescent nanoprobe for in vivo and in vitro cell tracking consecutively.Bioorganic & medicinal chemistry · 2019Article
- Mesoporous Silica Materials as Drug Delivery: "The Nightmare" of Bacterial Infection.Pharmaceutics · 2018Review
- Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.Virulence · 2018Article
- An optical probe for detecting chondrocyte apoptosis in response to mechanical injury.Scientific reports · 2017Article
- Design of a portable imager for near-infrared visualization of cutaneous wounds.Journal of biomedical optics · 2017Article
- Rapid and reagentless detection of microbial contamination within meat utilizing a smartphone-based biosensor.Scientific reports · 2014Article
- Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.PloS one · 2014Article
- Optical imaging of bacterial infections.Clinical and translational imagingReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Wound and device-associated infection is a leading cause for morbidity and mortality. As such, rapid and early diagnosis of bacterial colonization is critical to infection treatment. The current diagnostic methods however, are not able to meet this requirement. Therefore, there is a practical need for the development of a new method to rapidly identify colonized bacteria. This study aims to develop optical nanoprobes that can detect and quantify the number of colonized bacteria in real time. To this end, we have synthesized an imaging nanoprobe with three elements: Concanavalin A (Con A) as a bacterial targeting ligand, a nanoparticle carrier, and a near infrared fluorescent dye. An MTS assay revealed that the bacteria nanoprobe is cell compatible. In vitro testing further showed that the bacteria nanoprobe had a very high specificity and affinity to bacteria. Using a murine wound and catheter infection model, we found that the bacteria nanoprobes can rapidly detect and quantify the extent of bacterial colonization on wounds and catheters in real time.
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Registered trials
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