Evidence map›Paper›PMID 24734184›Full record

Trial reportJournal of pregnancy2014

Safety and efficacy of misoprostol versus oxytocin for the prevention of postpartum hemorrhage.

Minoo Rajaei, Samieh Karimi, Zohreh Shahboodaghi, Hamidreza Mahboobi, Tahereh Khorgoei, Farzam Rajaei

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pregnancy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01863706 (Safety and Efficacy of Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage), which is not on this map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01863706 phase1completednot on this map

Safety and Efficacy of Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage

TypeinterventionalSponsorHormozgan University of Medical SciencesRan2013 to 2013Enrolled400ConditionsPost Partum HemorrhageArmsMisoprostol, Oxytocin
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Cost-effectiveness of two interventions for the prevention of postpartum hemorrhage in Senegal.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2016
    Trial
  5. Advanced responder training priorities in Kenya: A Delphi study with implications for low- and middle- income countries.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Minoo RajaeiHormozgan Fertility and Infertility Research Center, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Iran.
Samieh KarimiHormozgan Fertility and Infertility Research Center, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Iran.
Zohreh ShahboodaghiHormozgan Fertility and Infertility Research Center, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Iran.
Hamidreza MahboobiInfectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas 7914964153, Iran ; Department of Psychology, Payame Noor University (PNU), Tehran, Iran.ORCID 0000-0002-3491-8050
Tahereh KhorgoeiInfectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas 7914964153, Iran.
Farzam RajaeiShiraz University of Medical Sciences (SUMS), Shiraz, Iran.
Hormozgan University of Medical Sciences · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postpartum hemorrhage (PPH) is the commonest cause of maternal death worldwide. Studies suggest that the use of misoprostol may be beneficial in clinical settings where oxytocin is unavailable. The aim of this study was to compare the safety and efficacy of oxytocin and misoprostol when used in the prevention of PPH. In a double-blind randomized controlled trial, 400 pregnant women who had a vaginal delivery were assigned into two groups: to receive either 20 IU of oxytocin in 1000 mL Ringer's solution and two placebo tablets or 400 mcg oral misoprostol (as two tablets) and 2 mL normal saline in 1000 mL Ringer's solution. The quantity of blood loss was higher in the oxytocin group in comparison to the misoprostol group. There was no significant difference in the decrease in hematocrit and hemoglobin between the two groups. Although there was no significant difference in the need for transfusions between the two groups, the patients in the oxytocin group had greater need for additional oxytocin. Results from this study indicate that it may be considered as an alternative for oxytocin in low resource clinical settings. This study is registered with ClinicalTrials.gov NCT01863706.

Indexed as

AdultBlood TransfusionDouble-Blind MethodFemaleHematocritHemoglobinsHumansMisoprostolOxytocicsOxytocinPostpartum HemorrhagePregnancyTreatment OutcomeYoung AdultHemoglobinsMisoprostolOxytocicsOxytocin

Identifiers

PMID24734184
PMCPMC3964754
OpenAlexW2021101593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.