ArticleFrontiers in immunology2014
Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naïve Mice.
Article in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- B1 Cells for Life.Immunological reviews · 2026Review
- Immunomodulatory activity of Inula viscosa (L.) compounds identified via LC-ESI-MS and their COX-2-targeted anti-inflammatory potential: in vitro, in vivo and in silico analysis.Journal of computer-aided molecular design · 2026Article
- Article
- B-1a cells scavenge NETs to attenuate sepsis.Journal of leukocyte biology · 2024Article
- Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity.Frontiers in immunology · 2024Article
- Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice.Transplantation · 2023Article
- B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles.Frontiers in toxicology · 2023Review
- Sex Influences Age-Related Changes in Natural Antibodies and CD5Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Chemokine Receptor-6 Promotes B-1 Cell Trafficking to Perivascular Adipose Tissue, Local IgM Production and Atheroprotection.Frontiers in immunology · 2021Article
- Antigen Receptor Specificity and Cell Location Influence the Diversification and Selection of the B-1a Cell Pool with Age.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- 2019 Russell Ross Memorial Lecture in Vascular Biology: B Lymphocyte-Mediated Protective Immunity in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.Circulation research · 2019Article
- Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- A Novel Role for C5a in B-1 Cell Homeostasis.Frontiers in immunology · 2018Article
- PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells.The Journal of experimental medicine · 2017Article
- B-1a Cells Protect Mice from Sepsis: Critical Role of CREB.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal.The Journal of biological chemistry · 2017Article
- Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B-1a cells constitutively secrete natural antibody that provides immediate protection against microbial pathogens and functions homeostatically to speed removal of apoptotic cell debris. Although B-1a cells are especially prominent in the peritoneal and pleural cavities, some B-1a cells reside in the spleen. A small subset of splenic B-1a cells in naïve, unimmunized mice express CD138, a recognized plasma cell antigen, whereas the bulk of splenic B-1a cells are CD138 negative. Splenic B-1a cells in toto have been shown to generate much more antibody per cell than peritoneal B-1a cells; however, specific functional information regarding CD138(+) splenic B-1a cells has been lacking. Here, we find a higher proportion of CD138(+) splenic B-1a cells spontaneously secrete more IgM as compared to CD138(-) B-1a cells. Moreover, IgM secreted by CD138(+) splenic B-1a cells is skewed with respect to N-region addition, and some aspects of VH and JH utilization, as compared to CD138(-) splenic B-1a cells and peritoneal B-1a cells. The small population of CD138(+) splenic B-1a cells is likely responsible for a substantial portion of natural IgM and differs from IgM produced by other B-1a cell subsets.
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